An introduction to health technology assessment and health economic evaluation: an online self-learning course

Isabell Wiethoff*, Silvia M. A. A. Evers, Michelle Michels, Mickael Hiligsmann

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


Cardiovascular diseases impose an enormous burden on patients and society. New health technologies promise to lower this burden; however, novel treatments often come at a high cost. In the Netherlands, health technology assessment (HTA) is increasingly being used to inform policy bodies about the optimal distribution of scarce healthcare resources and to guide decision-making about financing and reimbursement. In particular, economic evaluations, as one pillar of HTA, are frequently used to compare the costs and effects of different interventions. This paper aims to define HTA and its relevance to healthcare policy as well as providing a comprehensive overview of the methodology of economic evaluations targeting health professionals and researchers with limited prior knowledge of this subject. Accordingly, different types of economic evaluations are introduced, together with their respective costs and outcomes. Further, the results of economic evaluations are explained, along with techniques for performing them and methods for coping with uncertainty. In addition to this paper-based learning format, each chapter is complemented by a video lecture with further information and practical examples, helping to better understand and analyse health economic studies.
Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalNetherlands Heart Journal
Issue number1
Early online date1 May 2023
Publication statusPublished - Jun 2023


  • Health technology assessment
  • Economic evaluations
  • Cardiovascular disease
  • Resource use
  • Quality-adjusted life years
  • Health economics


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