An EEG Signature of Suicidal Behavior in Female Patients with Major Depressive Disorder? A Non-Replication

Noralie Krepel, Lars Benschop, Chris Baeken, Alexander T. Sack, Martijn Arns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

INTRODUCTION: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results.

METHODS: In the iSPOT-D sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12-15 Hz), beta (14.5-30 Hz), beta I (14.5-20 Hz), beta II (20-25 Hz), beta III (25-30 Hz), gamma I (31-49 Hz) using LORETA-software.

RESULTS: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals.

CONCLUSIONS: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study.

TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00693849 URL: http://clinicaltrials.gov/ct2/show/NCT00693849.

Original languageEnglish
Article number108058
JournalBiological Psychology
Early online date26 Feb 2021
DOIs
Publication statusPublished - Apr 2021

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