All roads lead to thrombus formation : demystifying platelet signaling pathways

    Research output: ThesisDoctoral ThesisInternal

    202 Downloads (Pure)

    Abstract

    Blood platelets have a central role in the process of haemostasis (the process of making the bleeding stop in a damaged blood vessel wall) and thrombosis (clotting of a blood vessel). The latter can lead to blood vessel obstruction causing a heart infarct or a stroke. The current antithrombotic, anti-blood vessel medication is only partly effective, and an increased risk of bleeding often creates a considerable complication. For the development of personalized target-specific medication with fewer side-effects a more exact knowledge of the complex process of thrombus formation and mainly the involved blood vessel signalling pathways is essential. The insight described in this thesis is a contribution to future developments in the treatment of arterial thrombosis.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • Heemskerk, Johan, Supervisor
    • Cosemans, Judith, Advisor
    Award date12 Nov 2012
    Place of PublicationMaastricht
    Publisher
    Print ISBNs9789090271507
    Publication statusPublished - 1 Jan 2012

    Keywords

    • Blood platelets
    • thrombus formation
    • signalling pathways

    Cite this