Aging and Vascular Disease: A Multidisciplinary Overview

Jeanette A. Maier*, Vicente Andres, Sara Castiglioni, Alessandro Giudici, Emily S. Lau, Janos Nemcsik, Francesca Seta, Paola Zaninotto, Mariella Catalano, Naomi M. Hamburg

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Vascular aging, i.e., the deterioration of the structure and function of the arteries over the life course, predicts cardiovascular events and mortality. Vascular degeneration can be recognized before becoming clinically symptomatic; therefore, its assessment allows the early identification of individuals at risk. This opens the possibility of minimizing disease progression. To review these issues, a search was completed using PubMed, MEDLINE, and Google Scholar from 2000 to date. As a network of clinicians and scientists involved in vascular medicine, we here describe the structural and functional age-dependent alterations of the arteries, the clinical tools for an early diagnosis of vascular aging, and the cellular and molecular events implicated. It emerges that more studies are necessary to identify the best strategy to quantify vascular aging, and to design proper physical activity programs, nutritional and pharmacological strategies, as well as social interventions to prevent, delay, and eventually revert the disease.
Original languageEnglish
Article number5512
Number of pages14
JournalJournal of Clinical Medicine
Volume12
Issue number17
DOIs
Publication statusPublished - 1 Sept 2023

Keywords

  • aging
  • arteries
  • cardiovascular diseases
  • SOCIAL-ISOLATION
  • ARTERIAL STIFFNESS
  • NITRIC-OXIDE
  • CARDIOVASCULAR-DISEASE
  • AGE
  • OLDER
  • RISK
  • LONELINESS
  • SCORE
  • CALCIFICATION

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