Age and prognosis in patients with pancreatic cancer: a population-based study

J.C. van Dongen, L.G.M. van der Geest, V.E. de Meijer, H.C. van Santvoort, J. de Vos-Geelen, M.G. Besselink, B.G. Koerkamp, J.W. Wilmink, C.H.J. van Eijck*, Dutch Pancreatic Canc Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: The diagnosis of pancreatic ductal adenocarcinoma (PDAC) has an enormous impact on patients, and even more so if they are of younger age. It is unclear how their treatment and outcome compare to older patients. This study compares clinicopathological characteristics and overall survival (OS) of PDAC patients agedMethod: This is a retrospective, population-based cohort study using Netherlands Cancer Registry data of patients diagnosed with PDAC (1 January 2015-31 December 2018). Kaplan-Meier curves and Cox proportional hazards models were used to assess OS.Results: Overall, 10,298 patients were included, of whom 1551 (15%) were <60 years. Patients <60 years were more often male, had better performance status, less comorbidities and less stage I disease, and more often received anticancer treatment (67 vs. 33%, p < 0.001) than older patients. Patients <60 years underwent resection of the tumour more often (22 vs. 14%p < 0.001), more often received chemotherapy, and had a better median OS (6.9 vs. 3.3 months, p < 0.001) compared to older patients. No differences in median OS were demonstrated between both age groups of patients who underwent resection (19.7 vs. 19.4 months, p = 0.123), received chemotherapy alone (7.8 vs. 8.5 months, p = 0.191), or received no anticancer treatment (1.8 vs. 1.9 months, p = 0.600). Patients <60 years with stage-IV disease receiving chemotherapy had a somewhat better OS (7.5 vs. 6.3 months, p = 0.026).Conclusion: Patients with PDAC <60 years more often underwent resection despite less stage I disease and had superior OS. Stratified for treatment, however, survival was largely similar.
Original languageEnglish
Pages (from-to)286-293
Number of pages8
JournalActa Oncologica
Issue number3
Early online date21 Dec 2021
Publication statusPublished - 4 Mar 2022


  • Pancreatic cancer
  • surgery
  • chemotherapy
  • population-based
  • survival
  • BRCA2


Dive into the research topics of 'Age and prognosis in patients with pancreatic cancer: a population-based study'. Together they form a unique fingerprint.

Cite this