Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist; Ahmed Ghallab; Rabea Graepel; Rosemarie Marchan; Reham Hassan; Susanne Hougaard Bennekou; Alice Limonciel; Mathieu Vinken; Stefan Schildknecht; Tanja Waldmann; Erik Danen; Ben van Ravenzwaay; Hennicke Kamp; Iain Gardner; Patricio Godoy; Frederic Y. Bois; Albert Braeuning; Raymond Reif; Franz Oesch; Dirk Drasdo; Stefan Hoehme; Michael Schwarz; Thomas Hartung; Thomas Braunbeck; Joost Beltman; Harry Vrieling; Ferran Sanz; Anna Forsby; Domenico Gadaleta; Ciaran Fisher; Jens Kelm; David Fluri; Gerhard Ecker; Barbara Zdrazil; Andrea Terron; Paul Jennings; Bart van der Burg; Steven Dooley; Annemarie H. Meijer; Egon Willighagen; Marvin Martens; Chris Evelo; Enrico Mombelli; Olivier Taboureau; Alberto Mantovani; Barry Hardy; Bjorn Koch; Sylvia Escher; Christoph van Thriel; Cristina Cadenas; D. Kroese; Bob van de Water; Jan G. Hengstler

doi:10.1007/s00204-017-2045-3

Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist^*, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patricio Godoy, Frederic Y. Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk DrasdoStefan Hoehme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost Beltman, Harry Vrieling, Ferran Sanz, Anna Forsby, Domenico Gadaleta, Ciaran Fisher, Jens Kelm, David Fluri, Gerhard Ecker, Barbara Zdrazil, Andrea Terron, Paul Jennings, Bart van der Burg, Steven Dooley, Annemarie H. Meijer, Egon Willighagen, Marvin Martens, Chris Evelo, Enrico Mombelli, Olivier Taboureau, Alberto Mantovani, Barry Hardy, Bjorn Koch, Sylvia Escher, Christoph van Thriel, Cristina Cadenas, D. Kroese, Bob van de Water, Jan G. Hengstler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	3477-3505
Number of pages	29
Journal	Archives of Toxicology
Volume	91
Issue number	11
DOIs	https://doi.org/10.1007/s00204-017-2045-3
Publication status	Published - Nov 2017

Keywords

Regulatory toxicology
Systems biology
Multi-scale integration
Computational toxicology
Interspecies extrapolation
Metabolism
Pathway unidirectionality
Liver fibrosis
Paracetamol
CCl4
Vinyl acetate
Tumor promotion
Binning of events
Multiple hit events Proof of non-toxicity
Prioritization of compounds
TUMOR-NECROSIS-FACTOR
EVIDENCE-BASED TOXICOLOGY
ACTIVATED STELLATE CELLS
NATURAL-KILLER-CELLS
LIVER FIBROSIS
DEVELOPMENTAL NEUROTOXICITY
RISK-ASSESSMENT
READ-ACROSS
ENVIRONMENTAL CHEMICALS
SYSTEMS TOXICOLOGY

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10.1007/s00204-017-2045-3

Full TextFinal published version, 2.6 MBLicence: Taverne

Cite this

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., ... Hengstler, J. G. (2017). Adverse outcome pathways: opportunities, limitations and open questions. Archives of Toxicology, 91(11), 3477-3505. https://doi.org/10.1007/s00204-017-2045-3

Leist, Marcel ; Ghallab, Ahmed ; Graepel, Rabea ; Marchan, Rosemarie ; Hassan, Reham ; Bennekou, Susanne Hougaard ; Limonciel, Alice ; Vinken, Mathieu ; Schildknecht, Stefan ; Waldmann, Tanja ; Danen, Erik ; van Ravenzwaay, Ben ; Kamp, Hennicke ; Gardner, Iain ; Godoy, Patricio ; Bois, Frederic Y. ; Braeuning, Albert ; Reif, Raymond ; Oesch, Franz ; Drasdo, Dirk ; Hoehme, Stefan ; Schwarz, Michael ; Hartung, Thomas ; Braunbeck, Thomas ; Beltman, Joost ; Vrieling, Harry ; Sanz, Ferran ; Forsby, Anna ; Gadaleta, Domenico ; Fisher, Ciaran ; Kelm, Jens ; Fluri, David ; Ecker, Gerhard ; Zdrazil, Barbara ; Terron, Andrea ; Jennings, Paul ; van der Burg, Bart ; Dooley, Steven ; Meijer, Annemarie H. ; Willighagen, Egon ; Martens, Marvin ; Evelo, Chris ; Mombelli, Enrico ; Taboureau, Olivier ; Mantovani, Alberto ; Hardy, Barry ; Koch, Bjorn ; Escher, Sylvia ; van Thriel, Christoph ; Cadenas, Cristina ; Kroese, D. ; van de Water, Bob ; Hengstler, Jan G. / Adverse outcome pathways : opportunities, limitations and open questions. In: Archives of Toxicology. 2017 ; Vol. 91, No. 11. pp. 3477-3505.

@article{7bb2620a514746d88a23cd39eb2f2471,

title = "Adverse outcome pathways: opportunities, limitations and open questions",

keywords = "Regulatory toxicology, Systems biology, Multi-scale integration, Computational toxicology, Interspecies extrapolation, Metabolism, Pathway unidirectionality, Liver fibrosis, Paracetamol, CCl4, Vinyl acetate, Tumor promotion, Binning of events, Multiple hit events Proof of non-toxicity, Prioritization of compounds, TUMOR-NECROSIS-FACTOR, EVIDENCE-BASED TOXICOLOGY, ACTIVATED STELLATE CELLS, NATURAL-KILLER-CELLS, LIVER FIBROSIS, DEVELOPMENTAL NEUROTOXICITY, RISK-ASSESSMENT, READ-ACROSS, ENVIRONMENTAL CHEMICALS, SYSTEMS TOXICOLOGY",

author = "Marcel Leist and Ahmed Ghallab and Rabea Graepel and Rosemarie Marchan and Reham Hassan and Bennekou, {Susanne Hougaard} and Alice Limonciel and Mathieu Vinken and Stefan Schildknecht and Tanja Waldmann and Erik Danen and {van Ravenzwaay}, Ben and Hennicke Kamp and Iain Gardner and Patricio Godoy and Bois, {Frederic Y.} and Albert Braeuning and Raymond Reif and Franz Oesch and Dirk Drasdo and Stefan Hoehme and Michael Schwarz and Thomas Hartung and Thomas Braunbeck and Joost Beltman and Harry Vrieling and Ferran Sanz and Anna Forsby and Domenico Gadaleta and Ciaran Fisher and Jens Kelm and David Fluri and Gerhard Ecker and Barbara Zdrazil and Andrea Terron and Paul Jennings and {van der Burg}, Bart and Steven Dooley and Meijer, {Annemarie H.} and Egon Willighagen and Marvin Martens and Chris Evelo and Enrico Mombelli and Olivier Taboureau and Alberto Mantovani and Barry Hardy and Bjorn Koch and Sylvia Escher and {van Thriel}, Christoph and Cristina Cadenas and D. Kroese and {van de Water}, Bob and Hengstler, {Jan G.}",

year = "2017",

month = nov,

doi = "10.1007/s00204-017-2045-3",

language = "English",

volume = "91",

pages = "3477--3505",

journal = "Archives of Toxicology",

issn = "0340-5761",

publisher = "Springer",

number = "11",

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Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, SH, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, FY, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Hoehme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, AH, Willighagen, E , Martens, M , Evelo, C, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, JG 2017, 'Adverse outcome pathways: opportunities, limitations and open questions', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505. https://doi.org/10.1007/s00204-017-2045-3

Adverse outcome pathways : opportunities, limitations and open questions. / Leist, Marcel; Ghallab, Ahmed; Graepel, Rabea; Marchan, Rosemarie; Hassan, Reham; Bennekou, Susanne Hougaard; Limonciel, Alice; Vinken, Mathieu; Schildknecht, Stefan; Waldmann, Tanja; Danen, Erik; van Ravenzwaay, Ben; Kamp, Hennicke; Gardner, Iain; Godoy, Patricio; Bois, Frederic Y.; Braeuning, Albert; Reif, Raymond; Oesch, Franz; Drasdo, Dirk; Hoehme, Stefan; Schwarz, Michael; Hartung, Thomas; Braunbeck, Thomas; Beltman, Joost; Vrieling, Harry; Sanz, Ferran; Forsby, Anna; Gadaleta, Domenico; Fisher, Ciaran; Kelm, Jens; Fluri, David; Ecker, Gerhard; Zdrazil, Barbara; Terron, Andrea; Jennings, Paul; van der Burg, Bart; Dooley, Steven; Meijer, Annemarie H.; Willighagen, Egon ; Martens, Marvin ; Evelo, Chris; Mombelli, Enrico; Taboureau, Olivier; Mantovani, Alberto; Hardy, Barry; Koch, Bjorn; Escher, Sylvia; van Thriel, Christoph; Cadenas, Cristina; Kroese, D.; van de Water, Bob; Hengstler, Jan G.

In: Archives of Toxicology, Vol. 91, No. 11, 11.2017, p. 3477-3505.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Adverse outcome pathways

T2 - opportunities, limitations and open questions

AU - Leist, Marcel

AU - Ghallab, Ahmed

AU - Graepel, Rabea

AU - Marchan, Rosemarie

AU - Hassan, Reham

AU - Bennekou, Susanne Hougaard

AU - Limonciel, Alice

AU - Vinken, Mathieu

AU - Schildknecht, Stefan

AU - Waldmann, Tanja

AU - Danen, Erik

AU - van Ravenzwaay, Ben

AU - Kamp, Hennicke

AU - Gardner, Iain

AU - Godoy, Patricio

AU - Bois, Frederic Y.

AU - Braeuning, Albert

AU - Reif, Raymond

AU - Oesch, Franz

AU - Drasdo, Dirk

AU - Hoehme, Stefan

AU - Schwarz, Michael

AU - Hartung, Thomas

AU - Braunbeck, Thomas

AU - Beltman, Joost

AU - Vrieling, Harry

AU - Sanz, Ferran

AU - Forsby, Anna

AU - Gadaleta, Domenico

AU - Fisher, Ciaran

AU - Kelm, Jens

AU - Fluri, David

AU - Ecker, Gerhard

AU - Zdrazil, Barbara

AU - Terron, Andrea

AU - Jennings, Paul

AU - van der Burg, Bart

AU - Dooley, Steven

AU - Meijer, Annemarie H.

AU - Willighagen, Egon

AU - Martens, Marvin

AU - Evelo, Chris

AU - Mombelli, Enrico

AU - Taboureau, Olivier

AU - Mantovani, Alberto

AU - Hardy, Barry

AU - Koch, Bjorn

AU - Escher, Sylvia

AU - van Thriel, Christoph

AU - Cadenas, Cristina

AU - Kroese, D.

AU - van de Water, Bob

AU - Hengstler, Jan G.

PY - 2017/11

Y1 - 2017/11

KW - Regulatory toxicology

KW - Systems biology

KW - Multi-scale integration

KW - Computational toxicology

KW - Interspecies extrapolation

KW - Metabolism

KW - Pathway unidirectionality

KW - Liver fibrosis

KW - Paracetamol

KW - CCl4

KW - Vinyl acetate

KW - Tumor promotion

KW - Binning of events

KW - Multiple hit events Proof of non-toxicity

KW - Prioritization of compounds

KW - TUMOR-NECROSIS-FACTOR

KW - EVIDENCE-BASED TOXICOLOGY

KW - ACTIVATED STELLATE CELLS

KW - NATURAL-KILLER-CELLS

KW - LIVER FIBROSIS

KW - DEVELOPMENTAL NEUROTOXICITY

KW - RISK-ASSESSMENT

KW - READ-ACROSS

KW - ENVIRONMENTAL CHEMICALS

KW - SYSTEMS TOXICOLOGY

U2 - 10.1007/s00204-017-2045-3

DO - 10.1007/s00204-017-2045-3

M3 - Article

C2 - 29051992

VL - 91

SP - 3477

EP - 3505

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

IS - 11

ER -