Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patricio Godoy, Frederic Y. Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk DrasdoStefan Hoehme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost Beltman, Harry Vrieling, Ferran Sanz, Anna Forsby, Domenico Gadaleta, Ciaran Fisher, Jens Kelm, David Fluri, Gerhard Ecker, Barbara Zdrazil, Andrea Terron, Paul Jennings, Bart van der Burg, Steven Dooley, Annemarie H. Meijer, Egon Willighagen, Marvin Martens, Chris Evelo, Enrico Mombelli, Olivier Taboureau, Alberto Mantovani, Barry Hardy, Bjorn Koch, Sylvia Escher, Christoph van Thriel, Cristina Cadenas, D. Kroese, Bob van de Water, Jan G. Hengstler

Research output: Contribution to journalArticleAcademicpeer-review

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Original languageEnglish
Pages (from-to)3477-3505
Number of pages29
JournalArchives of Toxicology
Volume91
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Regulatory toxicology
  • Systems biology
  • Multi-scale integration
  • Computational toxicology
  • Interspecies extrapolation
  • Metabolism
  • Pathway unidirectionality
  • Liver fibrosis
  • Paracetamol
  • CCl4
  • Vinyl acetate
  • Tumor promotion
  • Binning of events
  • Multiple hit events Proof of non-toxicity
  • Prioritization of compounds
  • TUMOR-NECROSIS-FACTOR
  • EVIDENCE-BASED TOXICOLOGY
  • ACTIVATED STELLATE CELLS
  • NATURAL-KILLER-CELLS
  • LIVER FIBROSIS
  • DEVELOPMENTAL NEUROTOXICITY
  • RISK-ASSESSMENT
  • READ-ACROSS
  • ENVIRONMENTAL CHEMICALS
  • SYSTEMS TOXICOLOGY

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