Advances in Microvasculair MRI Techniques: Breaking the Pathophysiological Barriers in Cerebral Small Vessel Disease

Cerebral microangiopathy is characterised by impaired cerebral vessels and is associated with ageing and cardiovascular risk factors. It increases the risk of ischemic stroke and dementia, which could lead to cognitive, physical and mental problems. The underlying pathophysiology is largely unknown. This dissertation examined whether advanced MRI (a non-invasive imaging technique) can provide functional information about pathophysiology. Imaging through contrast-enhanced and diffusion-weighted MRI scans revealed that cerebral microangiopathy is related to a leaking blood-brain barrier, reduced circulation and abnormal microvasculature and microstructure of the brain tissue. These measurements could be used as early markers for cerebral microangiopathy.