Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function

Michele Ciccarelli; Inês Falcão Pires; Johann Bauersachs; Luc Bertrand; Christophe Beauloye; Dana Dawson; Nazha Hamdani; Denise Hilfiker-Kleiner; Linda W van Laake; Frank Lezoualc'h; Wolfgang A Linke; Ida G Lunde; Peter P Rainer; Antonella Rispoli; Valeria Visco; Albino Carrizzo; Matteo Dal Ferro; Davide Stolfo; Jolanda van der Velden; Serena Zacchigna; Stephane Heymans; Thomas Thum; Carlo Gabriele Tocchetti

doi:10.1093/cvr/cvad088

Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function

Michele Ciccarelli^*, Inês Falcão Pires, Johann Bauersachs, Luc Bertrand, Christophe Beauloye, Dana Dawson, Nazha Hamdani, Denise Hilfiker-Kleiner, Linda W van Laake, Frank Lezoualc'h, Wolfgang A Linke, Ida G Lunde, Peter P Rainer, Antonella Rispoli, Valeria Visco, Albino Carrizzo, Matteo Dal Ferro, Davide Stolfo, Jolanda van der Velden, Serena ZacchignaStephane Heymans, Thomas Thum, Carlo Gabriele Tocchetti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.

Original language	English
Article number	cvad088
Pages (from-to)	2390-2404
Number of pages	15
Journal	Cardiovascular Research
Volume	119
Issue number	14
DOIs	https://doi.org/10.1093/cvr/cvad088
Publication status	Published - 15 Nov 2023

Keywords

Acute heart failure
New strategies
Phenotypes
Pre-clinical models
Scientific statement
Therapeutic management
Trajectories
Humans
Acute Disease
Prognosis
Heart Failure/diagnosis genetics therapy
Chronic Disease
Risk Factors

Access to Document

10.1093/cvr/cvad088

Cite this

Ciccarelli, M., Pires, I. F., Bauersachs, J., Bertrand, L., Beauloye, C., Dawson, D., Hamdani, N., Hilfiker-Kleiner, D., van Laake, L. W., Lezoualc'h, F., Linke, W. A., Lunde, I. G., Rainer, P. P., Rispoli, A., Visco, V., Carrizzo, A., Ferro, M. D., Stolfo, D., van der Velden, J., ... Tocchetti, C. G. (2023). Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function. Cardiovascular Research, 119(14), 2390-2404. Article cvad088. https://doi.org/10.1093/cvr/cvad088

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title = "Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function",

abstract = "While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.",

keywords = "Acute heart failure, New strategies, Phenotypes, Pre-clinical models, Scientific statement, Therapeutic management, Trajectories, Humans, Acute Disease, Prognosis, Heart Failure/diagnosis genetics therapy, Chronic Disease, Risk Factors",

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Ciccarelli, M, Pires, IF, Bauersachs, J, Bertrand, L, Beauloye, C, Dawson, D, Hamdani, N, Hilfiker-Kleiner, D, van Laake, LW, Lezoualc'h, F, Linke, WA, Lunde, IG, Rainer, PP, Rispoli, A, Visco, V, Carrizzo, A, Ferro, MD, Stolfo, D, van der Velden, J, Zacchigna, S, Heymans, S, Thum, T & Tocchetti, CG 2023, 'Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function', Cardiovascular Research, vol. 119, no. 14, cvad088, pp. 2390-2404. https://doi.org/10.1093/cvr/cvad088

TY - JOUR

T1 - Acute heart failure

T2 - mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function

AU - Ciccarelli, Michele

AU - Pires, Inês Falcão

AU - Bauersachs, Johann

AU - Bertrand, Luc

AU - Beauloye, Christophe

AU - Dawson, Dana

AU - Hamdani, Nazha

AU - Hilfiker-Kleiner, Denise

AU - van Laake, Linda W

AU - Lezoualc'h, Frank

AU - Linke, Wolfgang A

AU - Lunde, Ida G

AU - Rainer, Peter P

AU - Rispoli, Antonella

AU - Visco, Valeria

AU - Carrizzo, Albino

AU - Ferro, Matteo Dal

AU - Stolfo, Davide

AU - van der Velden, Jolanda

AU - Zacchigna, Serena

AU - Heymans, Stephane

AU - Thum, Thomas

AU - Tocchetti, Carlo Gabriele

PY - 2023/11/15

Y1 - 2023/11/15

N2 - While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.

AB - While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.

KW - Acute heart failure

KW - New strategies

KW - Phenotypes

KW - Pre-clinical models

KW - Scientific statement

KW - Therapeutic management

KW - Trajectories

KW - Humans

KW - Acute Disease

KW - Prognosis

KW - Heart Failure/diagnosis genetics therapy

KW - Chronic Disease

KW - Risk Factors

U2 - 10.1093/cvr/cvad088

DO - 10.1093/cvr/cvad088

M3 - Article

SN - 0008-6363

VL - 119

SP - 2390

EP - 2404

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 14

M1 - cvad088

ER -