Acetylcholine imaging in psychosis

Claudia Vingerhoets; Jan Booij; Therese van Amelsvoort

doi:10.1007/978-3-030-57231-0_15

Acetylcholine imaging in psychosis

Claudia Vingerhoets, Jan Booij, Therese van Amelsvoort^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Core symptoms of psychosis include delusions, hallucinations, motor symptoms, and cognitive impairments. The cholinergic system has been increasingly implied in the pathophysiology of psychotic disorders. PET and SPECT imaging can be useful tools to increase our insight in the role of the neurotransmitter acetylcholine in psychosis. In this chapter we will first globally describe cholinergic neurotransmission and the function of the nicotinic and muscarinic receptors. Second, we will provide an overview of PET and SPECT studies examining the cholinergic system in psychosis. Finally, we will briefly discuss the results of these studies as well as future directions.

Original language	English
Title of host publication	PET and SPECT in Psychiatry: Second Edition
Publisher	Springer International Publishing
Pages	525-539
Number of pages	15
ISBN (Electronic)	9783030572310
ISBN (Print)	9783030572303
DOIs	https://doi.org/10.1007/978-3-030-57231-0_15
Publication status	Published - 14 Dec 2020

Keywords

Acetylcholine
Muscarinic receptors
Nicotinic receptors
PET
Psychosis
Schizophrenia
SPECT

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10.1007/978-3-030-57231-0_15

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abstract = "Core symptoms of psychosis include delusions, hallucinations, motor symptoms, and cognitive impairments. The cholinergic system has been increasingly implied in the pathophysiology of psychotic disorders. PET and SPECT imaging can be useful tools to increase our insight in the role of the neurotransmitter acetylcholine in psychosis. In this chapter we will first globally describe cholinergic neurotransmission and the function of the nicotinic and muscarinic receptors. Second, we will provide an overview of PET and SPECT studies examining the cholinergic system in psychosis. Finally, we will briefly discuss the results of these studies as well as future directions.",

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T1 - Acetylcholine imaging in psychosis

AU - Vingerhoets, Claudia

AU - Booij, Jan

AU - van Amelsvoort, Therese

PY - 2020/12/14

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N2 - Core symptoms of psychosis include delusions, hallucinations, motor symptoms, and cognitive impairments. The cholinergic system has been increasingly implied in the pathophysiology of psychotic disorders. PET and SPECT imaging can be useful tools to increase our insight in the role of the neurotransmitter acetylcholine in psychosis. In this chapter we will first globally describe cholinergic neurotransmission and the function of the nicotinic and muscarinic receptors. Second, we will provide an overview of PET and SPECT studies examining the cholinergic system in psychosis. Finally, we will briefly discuss the results of these studies as well as future directions.

AB - Core symptoms of psychosis include delusions, hallucinations, motor symptoms, and cognitive impairments. The cholinergic system has been increasingly implied in the pathophysiology of psychotic disorders. PET and SPECT imaging can be useful tools to increase our insight in the role of the neurotransmitter acetylcholine in psychosis. In this chapter we will first globally describe cholinergic neurotransmission and the function of the nicotinic and muscarinic receptors. Second, we will provide an overview of PET and SPECT studies examining the cholinergic system in psychosis. Finally, we will briefly discuss the results of these studies as well as future directions.

KW - Acetylcholine

KW - Muscarinic receptors

KW - Nicotinic receptors

KW - PET

KW - Psychosis

KW - Schizophrenia

KW - SPECT

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M3 - Chapter

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SP - 525

EP - 539

BT - PET and SPECT in Psychiatry: Second Edition

PB - Springer International Publishing

ER -

Acetylcholine imaging in psychosis

Abstract

Keywords

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