Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly

Thijs R M Barten; Roos-Anne M P Bökkerink; Wulphert Venderink; Tom J G Gevers; Richard P G Ten Broek; Joost P H Drenth

doi:10.1111/liv.15177

Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly

Thijs R M Barten, Roos-Anne M P Bökkerink, Wulphert Venderink, Tom J G Gevers, Richard P G Ten Broek, Joost P H Drenth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND AND AIM: Polycystic liver disease (PLD) is related to hepatomegaly which causes an increased mechanical pressure on the abdominal wall. This may lead to abdominal wall herniation (AWH). We set out to establish the prevalence of AWH in PLD and explore risk factors.

METHODS: In this cross-sectional cohort study, we assessed the presence of AWHs from PLD patients with at least 1 abdominal computed tomography or magnetic resonance imaging scan. AWH presence on imaging was independently evaluated by two researchers. Data on potential risk factors were extracted from clinical files.

RESULTS: We included 484 patients of which 40.1% (n = 194) had an AWH. We found a clear predominance of umbilical hernias (25.8%, n = 125) while multiple hernias were present in 6.2% (n = 30). Using multivariate analysis, male sex (odds ratio [OR] 2.727 p < .001), abdominal surgery (OR 2.575, p < .001) and disease severity according to the Gigot classification (Type 3 OR 2.853, p < .001) were identified as risk factors. Height-adjusted total liver volume was an independent PLD-specific risk factor in the subgroup of patients with known total liver volume (OR 1.363, p = .001). Patients with multiple hernias were older (62.1 vs. 55.1, p = .001) and more frequently male (22.0% vs. 50.0%, p = .001).

CONCLUSION: AWHs occur frequently in PLD with a predominance of umbilical hernias. Hepatomegaly is a clear disease-specific risk factor.

Original language	English
Pages (from-to)	871-878
Number of pages	8
Journal	Liver International
Volume	42
Issue number	4
Early online date	17 Feb 2022
DOIs	https://doi.org/10.1111/liv.15177
Publication status	Published - Apr 2022

Keywords

CRITERIA
DIAGNOSIS
FENESTRATION
MANAGEMENT
MUSCLE
REPAIR
VOLUME
abdominal wall hernia
hepatomegaly
polycystic liver disease

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10.1111/liv.15177Licence: CC BY-NC-ND

Cite this

@article{110fc9dd97ca4312a11206d2b35272f8,

title = "Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly",

abstract = "BACKGROUND AND AIM: Polycystic liver disease (PLD) is related to hepatomegaly which causes an increased mechanical pressure on the abdominal wall. This may lead to abdominal wall herniation (AWH). We set out to establish the prevalence of AWH in PLD and explore risk factors.METHODS: In this cross-sectional cohort study, we assessed the presence of AWHs from PLD patients with at least 1 abdominal computed tomography or magnetic resonance imaging scan. AWH presence on imaging was independently evaluated by two researchers. Data on potential risk factors were extracted from clinical files.RESULTS: We included 484 patients of which 40.1% (n = 194) had an AWH. We found a clear predominance of umbilical hernias (25.8%, n = 125) while multiple hernias were present in 6.2% (n = 30). Using multivariate analysis, male sex (odds ratio [OR] 2.727 p < .001), abdominal surgery (OR 2.575, p < .001) and disease severity according to the Gigot classification (Type 3 OR 2.853, p < .001) were identified as risk factors. Height-adjusted total liver volume was an independent PLD-specific risk factor in the subgroup of patients with known total liver volume (OR 1.363, p = .001). Patients with multiple hernias were older (62.1 vs. 55.1, p = .001) and more frequently male (22.0% vs. 50.0%, p = .001).CONCLUSION: AWHs occur frequently in PLD with a predominance of umbilical hernias. Hepatomegaly is a clear disease-specific risk factor.",

keywords = "CRITERIA, DIAGNOSIS, FENESTRATION, MANAGEMENT, MUSCLE, REPAIR, VOLUME, abdominal wall hernia, hepatomegaly, polycystic liver disease",

author = "Barten, {Thijs R M} and B{\"o}kkerink, {Roos-Anne M P} and Wulphert Venderink and Gevers, {Tom J G} and {Ten Broek}, {Richard P G} and Drenth, {Joost P H}",

note = "{\textcopyright} 2022 The Authors. Liver International published by John Wiley & Sons Ltd.",

year = "2022",

month = apr,

doi = "10.1111/liv.15177",

language = "English",

volume = "42",

pages = "871--878",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly

AU - Barten, Thijs R M

AU - Bökkerink, Roos-Anne M P

AU - Venderink, Wulphert

AU - Gevers, Tom J G

AU - Ten Broek, Richard P G

AU - Drenth, Joost P H

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND AND AIM: Polycystic liver disease (PLD) is related to hepatomegaly which causes an increased mechanical pressure on the abdominal wall. This may lead to abdominal wall herniation (AWH). We set out to establish the prevalence of AWH in PLD and explore risk factors.METHODS: In this cross-sectional cohort study, we assessed the presence of AWHs from PLD patients with at least 1 abdominal computed tomography or magnetic resonance imaging scan. AWH presence on imaging was independently evaluated by two researchers. Data on potential risk factors were extracted from clinical files.RESULTS: We included 484 patients of which 40.1% (n = 194) had an AWH. We found a clear predominance of umbilical hernias (25.8%, n = 125) while multiple hernias were present in 6.2% (n = 30). Using multivariate analysis, male sex (odds ratio [OR] 2.727 p < .001), abdominal surgery (OR 2.575, p < .001) and disease severity according to the Gigot classification (Type 3 OR 2.853, p < .001) were identified as risk factors. Height-adjusted total liver volume was an independent PLD-specific risk factor in the subgroup of patients with known total liver volume (OR 1.363, p = .001). Patients with multiple hernias were older (62.1 vs. 55.1, p = .001) and more frequently male (22.0% vs. 50.0%, p = .001).CONCLUSION: AWHs occur frequently in PLD with a predominance of umbilical hernias. Hepatomegaly is a clear disease-specific risk factor.

AB - BACKGROUND AND AIM: Polycystic liver disease (PLD) is related to hepatomegaly which causes an increased mechanical pressure on the abdominal wall. This may lead to abdominal wall herniation (AWH). We set out to establish the prevalence of AWH in PLD and explore risk factors.METHODS: In this cross-sectional cohort study, we assessed the presence of AWHs from PLD patients with at least 1 abdominal computed tomography or magnetic resonance imaging scan. AWH presence on imaging was independently evaluated by two researchers. Data on potential risk factors were extracted from clinical files.RESULTS: We included 484 patients of which 40.1% (n = 194) had an AWH. We found a clear predominance of umbilical hernias (25.8%, n = 125) while multiple hernias were present in 6.2% (n = 30). Using multivariate analysis, male sex (odds ratio [OR] 2.727 p < .001), abdominal surgery (OR 2.575, p < .001) and disease severity according to the Gigot classification (Type 3 OR 2.853, p < .001) were identified as risk factors. Height-adjusted total liver volume was an independent PLD-specific risk factor in the subgroup of patients with known total liver volume (OR 1.363, p = .001). Patients with multiple hernias were older (62.1 vs. 55.1, p = .001) and more frequently male (22.0% vs. 50.0%, p = .001).CONCLUSION: AWHs occur frequently in PLD with a predominance of umbilical hernias. Hepatomegaly is a clear disease-specific risk factor.

KW - CRITERIA

KW - DIAGNOSIS

KW - FENESTRATION

KW - MANAGEMENT

KW - MUSCLE

KW - REPAIR

KW - VOLUME

KW - abdominal wall hernia

KW - hepatomegaly

KW - polycystic liver disease

U2 - 10.1111/liv.15177

DO - 10.1111/liv.15177

M3 - Article

C2 - 35129293

SN - 1478-3223

VL - 42

SP - 871

EP - 878

JO - Liver International

JF - Liver International

IS - 4

ER -