A treatment algorithm for patients with large skull bone defects and first results

Bernd Lethaus*, Marielle Poort ter Laak, Paul Laeven, Maikel Beerens, David Koper, Jules Poukens, Peter Kessler

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Web of Science)


Large skull bone defects resulting from craniotomies due to cerebral insults, trauma or tumours create functional and aesthetic disturbances to the patient. The reconstruction of large osseous defects is still challenging. A treatment algorithm is presented based on the close interaction of radiologists, computer engineers and cranio-maxillofacial surgeons. From 2004 until today twelve consecutive patients have been operated on successfully according to this treatment plan. Titanium and polyetheretherketone (PEEK) were used to manufacture the implants. The treatment algorithm is proved to be reliable. No corrections had to be performed either to the skull bone or to the implant. Short operations and hospitalization periods are essential prerequisites for treatment success and justify the high expenses.
Original languageEnglish
Pages (from-to)435-440
JournalJournal of Cranio-Maxillofacial Surgery
Issue number6
Publication statusPublished - Sept 2011


  • Cranioplasty
  • CAD
  • CAM
  • PEEK
  • Titanium

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