A standard calculation methodology for human doubly labeled water studies

J.R. Speakman; Y. Yamada; H. Sagayama; E.S.F. Berman; P.N. Ainslie; L.F. Andersen; L.J. Anderson; L. Arab; I. Baddou; K. Bedu-Addo; E.E. Blaak; S. Blanc; A.G. Bonomi; C.V.C. Bouten; P. Bovet; M.S. Buchowski; N.F. Butte; S.G.J.A. Camps; G.L. Close; J.A. Cooper; S.A. Creasy; S.K. Das; R. Cooper; L.R. Dugas; C.B. Ebbeling; U. Ekelund; S. Entringer; T. Forrester; B.W. Fudge; A.H. Goris; M. Gurven; C. Hambly; A. El Hamdouchi; M.B. Hoos; S.M. Hu; N. Joonas; A.M. Joosen; P. Katzmarzyk; K.P. Kempen; M. Kimura; W.E. Kraus; R.F. Kushner; E.V. Lambert; W.R. Leonard; N. Lessan; D.S. Ludwig; C.K. Martin; A.C. Medin; E.P. Meijer; J.C. Morehen; Guy Plasqui; Giulio Valenti; Ludo M. Van Etten; Klaas Westerterp; IAEA DLW database group

doi:10.1016/j.xcrm.2021.100203

A standard calculation methodology for human doubly labeled water studies

J.R. Speakman^*, Y. Yamada^*, H. Sagayama^*, E.S.F. Berman, P.N. Ainslie, L.F. Andersen, L.J. Anderson, L. Arab, I. Baddou, K. Bedu-Addo, E.E. Blaak, S. Blanc, A.G. Bonomi, C.V.C. Bouten, P. Bovet, M.S. Buchowski, N.F. Butte, S.G.J.A. Camps, G.L. Close, J.A. CooperS.A. Creasy, S.K. Das, R. Cooper, L.R. Dugas, C.B. Ebbeling, U. Ekelund, S. Entringer, T. Forrester, B.W. Fudge, A.H. Goris, M. Gurven, C. Hambly, A. El Hamdouchi, M.B. Hoos, S.M. Hu, N. Joonas, A.M. Joosen, P. Katzmarzyk, K.P. Kempen, M. Kimura, W.E. Kraus, R.F. Kushner, E.V. Lambert, W.R. Leonard, N. Lessan, D.S. Ludwig, C.K. Martin, A.C. Medin, E.P. Meijer, J.C. Morehen, Guy Plasqui, Giulio Valenti, Ludo M. Van Etten, Klaas Westerterp, IAEA DLW database group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO(2) is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO(2) over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Original language	English
Article number	100203
Number of pages	13
Journal	Cell Reports Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.xcrm.2021.100203
Publication status	Published - 16 Feb 2021

Keywords

(H2O)-H-2-O-18 METHOD
BODY-WATER
CARBON-DIOXIDE PRODUCTION
CO2 PRODUCTION
DILUTION SPACE RATIO
ENERGY-EXPENDITURE
H-2
INDIRECT CALORIMETRY
O-18
VALIDATION
INFANTS

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Cite this

Speakman, J. R., Yamada, Y., Sagayama, H., Berman, E. S. F., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., ... IAEA DLW database group (2021). A standard calculation methodology for human doubly labeled water studies. Cell Reports Medicine, 2(2), Article 100203. https://doi.org/10.1016/j.xcrm.2021.100203

@article{8180c7432ce24237aa48b8b467317edf,

title = "A standard calculation methodology for human doubly labeled water studies",

abstract = "The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO(2) is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO(2) over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.",

keywords = "(H2O)-H-2-O-18 METHOD, BODY-WATER, CARBON-DIOXIDE PRODUCTION, CO2 PRODUCTION, DILUTION SPACE RATIO, ENERGY-EXPENDITURE, H-2, INDIRECT CALORIMETRY, O-18, VALIDATION, INFANTS",

author = "J.R. Speakman and Y. Yamada and H. Sagayama and E.S.F. Berman and P.N. Ainslie and L.F. Andersen and L.J. Anderson and L. Arab and I. Baddou and K. Bedu-Addo and E.E. Blaak and S. Blanc and A.G. Bonomi and C.V.C. Bouten and P. Bovet and M.S. Buchowski and N.F. Butte and S.G.J.A. Camps and G.L. Close and J.A. Cooper and S.A. Creasy and S.K. Das and R. Cooper and L.R. Dugas and C.B. Ebbeling and U. Ekelund and S. Entringer and T. Forrester and B.W. Fudge and A.H. Goris and M. Gurven and C. Hambly and {El Hamdouchi}, A. and M.B. Hoos and S.M. Hu and N. Joonas and A.M. Joosen and P. Katzmarzyk and K.P. Kempen and M. Kimura and W.E. Kraus and R.F. Kushner and E.V. Lambert and W.R. Leonard and N. Lessan and D.S. Ludwig and C.K. Martin and A.C. Medin and E.P. Meijer and J.C. Morehen and Guy Plasqui and Giulio Valenti and {Van Etten}, {Ludo M.} and Klaas Westerterp and {IAEA DLW database group}",

note = "{\textcopyright} 2021 The Authors.",

year = "2021",

month = feb,

day = "16",

doi = "10.1016/j.xcrm.2021.100203",

language = "English",

volume = "2",

journal = "Cell Reports Medicine",

issn = "2666-3791",

publisher = "Cell Press",

number = "2",

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Speakman, JR, Yamada, Y, Sagayama, H, Berman, ESF, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Creasy, SA, Das, SK, Cooper, R, Dugas, LR, Ebbeling, CB, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, SM, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Ludwig, DS, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Plasqui, G, Valenti, G, Van Etten, LM, Westerterp, K & IAEA DLW database group 2021, 'A standard calculation methodology for human doubly labeled water studies', Cell Reports Medicine, vol. 2, no. 2, 100203. https://doi.org/10.1016/j.xcrm.2021.100203

TY - JOUR

T1 - A standard calculation methodology for human doubly labeled water studies

AU - Speakman, J.R.

AU - Yamada, Y.

AU - Sagayama, H.

AU - Berman, E.S.F.

AU - Ainslie, P.N.

AU - Andersen, L.F.

AU - Anderson, L.J.

AU - Arab, L.

AU - Baddou, I.

AU - Bedu-Addo, K.

AU - Blaak, E.E.

AU - Blanc, S.

AU - Bonomi, A.G.

AU - Bouten, C.V.C.

AU - Bovet, P.

AU - Buchowski, M.S.

AU - Butte, N.F.

AU - Camps, S.G.J.A.

AU - Close, G.L.

AU - Cooper, J.A.

AU - Creasy, S.A.

AU - Das, S.K.

AU - Cooper, R.

AU - Dugas, L.R.

AU - Ebbeling, C.B.

AU - Ekelund, U.

AU - Entringer, S.

AU - Forrester, T.

AU - Fudge, B.W.

AU - Goris, A.H.

AU - Gurven, M.

AU - Hambly, C.

AU - El Hamdouchi, A.

AU - Hoos, M.B.

AU - Hu, S.M.

AU - Joonas, N.

AU - Joosen, A.M.

AU - Katzmarzyk, P.

AU - Kempen, K.P.

AU - Kimura, M.

AU - Kraus, W.E.

AU - Kushner, R.F.

AU - Lambert, E.V.

AU - Leonard, W.R.

AU - Lessan, N.

AU - Ludwig, D.S.

AU - Martin, C.K.

AU - Medin, A.C.

AU - Meijer, E.P.

AU - Morehen, J.C.

AU - Plasqui, Guy

AU - Valenti, Giulio

AU - Van Etten, Ludo M.

AU - Westerterp, Klaas

AU - IAEA DLW database group

PY - 2021/2/16

Y1 - 2021/2/16

N2 - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO(2) is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO(2) over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

AB - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO(2) is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO(2) over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

KW - (H2O)-H-2-O-18 METHOD

KW - BODY-WATER

KW - CARBON-DIOXIDE PRODUCTION

KW - CO2 PRODUCTION

KW - DILUTION SPACE RATIO

KW - ENERGY-EXPENDITURE

KW - H-2

KW - INDIRECT CALORIMETRY

KW - O-18

KW - VALIDATION

KW - INFANTS

U2 - 10.1016/j.xcrm.2021.100203

DO - 10.1016/j.xcrm.2021.100203

M3 - Article

C2 - 33665639

SN - 2666-3791

VL - 2

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 2

M1 - 100203

ER -