A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.

Original languageEnglish
Pages (from-to)1349-1360
Number of pages12
JournalChemsuschem
Volume12
Issue number7
DOIs
Publication statusPublished - 5 Apr 2019

Keywords

  • BAEYER-VILLIGER OXIDATION
  • CHEMICALS
  • CONDENSATION
  • ENVIRONMENTAL ASSESSMENT
  • GREEN CHEMISTRY
  • ISOPHORONE
  • METRICS
  • MONOOXYGENASES
  • SCALE
  • SUSTAINABILITY
  • biocatalysis
  • life cycle assessment
  • oxidative chemistry
  • process metrics
  • sustainable chemistry

Cite this

@article{3b55cad32ce9476c89001cf7f2c99d4a,
title = "A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry",
abstract = "Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71{\%} if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.",
keywords = "BAEYER-VILLIGER OXIDATION, CHEMICALS, CONDENSATION, ENVIRONMENTAL ASSESSMENT, GREEN CHEMISTRY, ISOPHORONE, METRICS, MONOOXYGENASES, SCALE, SUSTAINABILITY, biocatalysis, life cycle assessment, oxidative chemistry, process metrics, sustainable chemistry",
author = "Marie Delgove and Achille-B. Laurent and John Woodley and {de Wildeman}, Stefaan and Katrien Bernaerts and {van der Meer}, Yvonne",
year = "2019",
month = "4",
day = "5",
doi = "10.1002/cssc.201900007",
language = "English",
volume = "12",
pages = "1349--1360",
journal = "Chemsuschem",
issn = "1864-5631",
publisher = "Wiley-VCH Verlag",
number = "7",

}

TY - JOUR

T1 - A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry

AU - Delgove, Marie

AU - Laurent, Achille-B.

AU - Woodley, John

AU - de Wildeman, Stefaan

AU - Bernaerts, Katrien

AU - van der Meer, Yvonne

PY - 2019/4/5

Y1 - 2019/4/5

N2 - Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.

AB - Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.

KW - BAEYER-VILLIGER OXIDATION

KW - CHEMICALS

KW - CONDENSATION

KW - ENVIRONMENTAL ASSESSMENT

KW - GREEN CHEMISTRY

KW - ISOPHORONE

KW - METRICS

KW - MONOOXYGENASES

KW - SCALE

KW - SUSTAINABILITY

KW - biocatalysis

KW - life cycle assessment

KW - oxidative chemistry

KW - process metrics

KW - sustainable chemistry

U2 - 10.1002/cssc.201900007

DO - 10.1002/cssc.201900007

M3 - Article

VL - 12

SP - 1349

EP - 1360

JO - Chemsuschem

JF - Chemsuschem

SN - 1864-5631

IS - 7

ER -