Abstract
Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.
Original language | English |
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Pages (from-to) | 1349-1360 |
Number of pages | 12 |
Journal | Chemsuschem |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - 5 Apr 2019 |
Keywords
- BAEYER-VILLIGER OXIDATION
- CHEMICALS
- CONDENSATION
- ENVIRONMENTAL ASSESSMENT
- GREEN CHEMISTRY
- ISOPHORONE
- METRICS
- MONOOXYGENASES
- SCALE
- SUSTAINABILITY
- biocatalysis
- life cycle assessment
- oxidative chemistry
- process metrics
- sustainable chemistry