A Novel Mapping Strategy of Repetitive Patterns in Consecutive Recordings to Localize Atrial Fibrillation Sources: an In-Silico Study

Victor Gonçalves Marques*, Ali Gharaviri2, Simone Pezzuto, Angelo Auricchio, Pietro Bonizzi, Stef Zeemering, Ulrich Schotten

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

50 Downloads (Pure)

Abstract

In some patients with persistent atrial fibrillation (AF), localized functional mechanisms may sustain AF and thus represent ablation targets. We propose a novel mapping strategy to locate AF sources by combining repetitive patterns from consecutive high-density mapping recordings. The algorithm moves the catheter iteratively upstream of the main repetitive conduction direction to identify an AF source either by direct classification of local activation patterns or by encircling it. We tested the performance and robustness of this approach in two groups of detailed AF simulations, without and with severe structural remodeling (N=20 per group, 20 starting positions per simulation), using a 4times 4 grid mapping catheter (3mm spacing). Structural remodeling led to more simultaneous sources (median [IQR], 2 [1; 3] vs 3 [2; 5], p < 0.001) that meandered in larger areas (127.5 [82.0; 216.0] vs 188.0 [121.2; 305.5] mm2, p < 0.05. The mapping approach localized a source in 6 [4; 9] vs. 5 [5; 8] steps for the groups without and with structural remodeling (p < 0.001), with an accuracy of 11 [7; 16] vs 9 [6; 14] mm (p=0.046). Sources were localized by encircling in 62.6% vs. 41.4% of the detection in both groups, respectively. The proposed mapping strategy detected AF sources accurately within a few steps, even in complex AF substrates, with a substantial contribution of encircling to detect sources.

Original languageEnglish
Title of host publicationComputing in Cardiology (CinC)
PublisherIEEE Computer Society
Number of pages4
Volume50
ISBN (Electronic)9798350382525
DOIs
Publication statusPublished - 2023
Event50th Computing in Cardiology conference 2023 - Atlanta, United States
Duration: 1 Oct 20234 Oct 2023
https://cinc2023.org/

Publication series

SeriesComputing in Cardiology
ISSN2325-8861

Conference

Conference50th Computing in Cardiology conference 2023
Abbreviated titleCinC 2023
Country/TerritoryUnited States
CityAtlanta
Period1/10/234/10/23
Internet address

Fingerprint

Dive into the research topics of 'A Novel Mapping Strategy of Repetitive Patterns in Consecutive Recordings to Localize Atrial Fibrillation Sources: an In-Silico Study'. Together they form a unique fingerprint.

Cite this