A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease

Mattia Arlotti; Matteo Colombo; Andrea Bonfanti; Tomasz Mandat; Michele Maria Lanotte; Elena Pirola; Linda Borellini; Paolo Rampini; Roberto Eleopra; Sara Rinaldo; Luigi Romito; Marcus L F Janssen; Alberto Priori; Sara Marceglia

doi:10.3389/fnins.2021.763235

A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease

Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L F Janssen, Alberto Priori, Sara Marceglia^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson's disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

Original language	English
Article number	763235
Number of pages	12
Journal	Frontiers in Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fnins.2021.763235
Publication status	Published - 7 Dec 2021

Keywords

deep brain stimulation
neuromodulation
closed-loop
local field potential (LFP)
Parkinson's disease
neural interface
implantable device
DEEP BRAIN-STIMULATION
LOCAL-FIELD POTENTIALS
ARTIFACT
DEVICE
PERSPECTIVES
OSCILLATIONS
SUPPRESSION
LEVODOPA
DBS

Access to Document

10.3389/fnins.2021.763235Licence: CC BY

Cite this

Arlotti, M., Colombo, M., Bonfanti, A., Mandat, T., Lanotte, M. M., Pirola, E., Borellini, L., Rampini, P., Eleopra, R., Rinaldo, S., Romito, L., Janssen, M. L. F., Priori, A., & Marceglia, S. (2021). A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease. Frontiers in Neuroscience, 15, Article 763235. https://doi.org/10.3389/fnins.2021.763235

@article{ede2c601bea04f60b0438273433218d4,

title = "A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease",

abstract = "Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson's disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.",

keywords = "deep brain stimulation, neuromodulation, closed-loop, local field potential (LFP), Parkinson's disease, neural interface, implantable device, DEEP BRAIN-STIMULATION, LOCAL-FIELD POTENTIALS, ARTIFACT, DEVICE, PERSPECTIVES, OSCILLATIONS, SUPPRESSION, LEVODOPA, DBS",

author = "Mattia Arlotti and Matteo Colombo and Andrea Bonfanti and Tomasz Mandat and Lanotte, {Michele Maria} and Elena Pirola and Linda Borellini and Paolo Rampini and Roberto Eleopra and Sara Rinaldo and Luigi Romito and Janssen, {Marcus L F} and Alberto Priori and Sara Marceglia",

note = "Copyright {\textcopyright} 2021 Arlotti, Colombo, Bonfanti, Mandat, Lanotte, Pirola, Borellini, Rampini, Eleopra, Rinaldo, Romito, Janssen, Priori and Marceglia.",

year = "2021",

month = dec,

day = "7",

doi = "10.3389/fnins.2021.763235",

language = "English",

volume = "15",

journal = "Frontiers in Neuroscience",

issn = "1662-4548",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - A New Implantable Closed-Loop Clinical Neural Interface

T2 - First Application in Parkinson's Disease

AU - Arlotti, Mattia

AU - Colombo, Matteo

AU - Bonfanti, Andrea

AU - Mandat, Tomasz

AU - Lanotte, Michele Maria

AU - Pirola, Elena

AU - Borellini, Linda

AU - Rampini, Paolo

AU - Eleopra, Roberto

AU - Rinaldo, Sara

AU - Romito, Luigi

AU - Janssen, Marcus L F

AU - Priori, Alberto

AU - Marceglia, Sara

PY - 2021/12/7

Y1 - 2021/12/7

N2 - Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson's disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

AB - Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson's disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

KW - deep brain stimulation

KW - neuromodulation

KW - closed-loop

KW - local field potential (LFP)

KW - Parkinson's disease

KW - neural interface

KW - implantable device

KW - DEEP BRAIN-STIMULATION

KW - LOCAL-FIELD POTENTIALS

KW - ARTIFACT

KW - DEVICE

KW - PERSPECTIVES

KW - OSCILLATIONS

KW - SUPPRESSION

KW - LEVODOPA

KW - DBS

U2 - 10.3389/fnins.2021.763235

DO - 10.3389/fnins.2021.763235

M3 - Article

C2 - 34949982

SN - 1662-4548

VL - 15

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

M1 - 763235

ER -