A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

Folkert Verkaar, Guido J. R. Zaman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Wnts control mammalian developmental morphogenesis and are critical for adult stem cell maintenance. Wnts initiate several intracellular signaling cascades, such as Wnt/beta-catenin-, Wnt/Ca(2+)-and Wnt/ROR2-signaling. Signaling preference of Wnts for these various pathways is thought to depend on the repertoire of receptors present on recipient cells. Here, we propose a further refinement of this receptor model and hypothesize that Wnt signaling specificity depends on co-receptor recruitment upon binding of Wnt to Frizzled receptor molecules. In this model, recruitment of LRP5/6 leads to activation of Wnt/beta-catenin signaling, whereas signaling through other pathways is mediated by recruiting ROR2.
Original languageEnglish
Pages (from-to)3850-3854
JournalFebs Letters
Issue number18
Publication statusPublished - 24 Sept 2010


  • Frizzled-2
  • ROR2
  • Wnt-3a
  • Wnt-5a

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