Abstract
Wnts control mammalian developmental morphogenesis and are critical for adult stem cell maintenance. Wnts initiate several intracellular signaling cascades, such as Wnt/beta-catenin-, Wnt/Ca(2+)-and Wnt/ROR2-signaling. Signaling preference of Wnts for these various pathways is thought to depend on the repertoire of receptors present on recipient cells. Here, we propose a further refinement of this receptor model and hypothesize that Wnt signaling specificity depends on co-receptor recruitment upon binding of Wnt to Frizzled receptor molecules. In this model, recruitment of LRP5/6 leads to activation of Wnt/beta-catenin signaling, whereas signaling through other pathways is mediated by recruiting ROR2.
Original language | English |
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Pages (from-to) | 3850-3854 |
Journal | Febs Letters |
Volume | 584 |
Issue number | 18 |
DOIs | |
Publication status | Published - 24 Sept 2010 |
Keywords
- Frizzled-2
- ROR2
- Wnt-3a
- Wnt-5a