A gene variation (rs12691) in the CCAT/enhancer binding protein α modulates glucose metabolism in metabolic syndrome.

J. Delgado Lista, P. Perez Martinez, A. Garcia Rios, C.M. Phillips, W Hall, I.M. Gjelstad, D. Lairon, W. Saris, B. Kiec Wilk, B. Karlstrom, C.A. Drevon, C. Defoort, E.E. Blaak, A. Dembinska Kiec, U. Riserus, J.A. Lovegrove, H.M. Roche, J. Lopez Miranda*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND AND AIMS: CCAAT/enhancer-binding protein alpha (CEBPA) is a transcription factor involved in adipogenesis and energy homeostasis. Caloric restriction reduces CEBPA protein expression in patients with metabolic syndrome (MetS). A previous report linked rs12691 SNP in CEBPA to altered concentration of fasting triglycerides. Our objective was to assess the effects of rs12691 in glucose metabolism in Metabolic Syndrome (MetS) patients. METHODS AND RESULTS: Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. Carriers of the minor A allele of rs12691 had altered disposition index (p = 0.0003), lower acute insulin response (p = 0.005) and a lower insulin sensitivity index (p = 0.025) indicating a lower insulin sensitivity and a lower insulin secretion, at baseline and at the end of the diets. Furthermore, A allele carriers displayed lower HDL concentration. CONCLUSION: The presence of the A allele of rs12691 influences glucose metabolism of MetS patients. Clinical Trials Registry number NCT00429195.
Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalNutrition Metabolism and Cardiovascular Diseases
Issue number5
Publication statusPublished - May 2013


  • Metabolic syndrome
  • CEBP alpha
  • C/EBP alpha
  • insulin secretion
  • insulin resistance
  • CELL
  • MAX
  • MEN


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