A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

Anandkumar Nandakumar; Roman Truckenmuller; Maqsood Ahmed; Febriyani Damanik; Diogo Reis Santos; Nils Auffermann; Jan de Boer; Pamela Habibovic; Clemens van Blitterswijk; Lorenzo Moroni

doi:10.1002/smll.201300220

A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

Anandkumar Nandakumar, Roman Truckenmuller, Maqsood Ahmed, Febriyani Damanik, Diogo Reis Santos, Nils Auffermann, Jan de Boer, Pamela Habibovic, Clemens van Blitterswijk, Lorenzo Moroni^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	3405-3409
Number of pages	5
Journal	Small
Volume	9
Issue number	20
DOIs	https://doi.org/10.1002/smll.201300220
Publication status	Published - 25 Oct 2013
Externally published	Yes

Keywords

electrospinning
patterning
physiological temperatures
biomedical engineering
fibers
MESENCHYMAL STEM-CELLS
SCAFFOLDS
DIFFERENTIATION
BIOMATERIALS
EXPRESSION
SURFACES
GROWTH

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10.1002/smll.201300220

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title = "A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures",

abstract = "Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "electrospinning, patterning, physiological temperatures, biomedical engineering, fibers, MESENCHYMAL STEM-CELLS, SCAFFOLDS, DIFFERENTIATION, BIOMATERIALS, EXPRESSION, SURFACES, GROWTH",

author = "Anandkumar Nandakumar and Roman Truckenmuller and Maqsood Ahmed and Febriyani Damanik and {Reis Santos}, Diogo and Nils Auffermann and {de Boer}, Jan and Pamela Habibovic and {van Blitterswijk}, Clemens and Lorenzo Moroni",

year = "2013",

month = oct,

day = "25",

doi = "10.1002/smll.201300220",

language = "English",

volume = "9",

pages = "3405--3409",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

AU - Nandakumar, Anandkumar

AU - Truckenmuller, Roman

AU - Ahmed, Maqsood

AU - Damanik, Febriyani

AU - Reis Santos, Diogo

AU - Auffermann, Nils

AU - de Boer, Jan

AU - Habibovic, Pamela

AU - van Blitterswijk, Clemens

AU - Moroni, Lorenzo

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - electrospinning

KW - patterning

KW - physiological temperatures

KW - biomedical engineering

KW - fibers

KW - MESENCHYMAL STEM-CELLS

KW - SCAFFOLDS

KW - DIFFERENTIATION

KW - BIOMATERIALS

KW - EXPRESSION

KW - SURFACES

KW - GROWTH

U2 - 10.1002/smll.201300220

DO - 10.1002/smll.201300220

M3 - Article

SN - 1613-6810

VL - 9

SP - 3405

EP - 3409

JO - Small

JF - Small

IS - 20

ER -

A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures

Abstract

Keywords

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