TY - JOUR
T1 - A combined trauma model of chest and abdominal trauma with hemorrhagic shock--description of a new porcine model
AU - Hildebrand, Frank
AU - Weuster, Matthias
AU - Mommsen, Philipp
AU - Mohr, Juliane
AU - Fröhlich, Matthias
AU - Witte, Ingo
AU - Keibl, Claudia
AU - Ruchholtz, Steffen
AU - Seekamp, Andreas
AU - Pape, Hans-Christoph
AU - Flohe, Sascha
AU - van Griensven, Martijn
PY - 2012/12
Y1 - 2012/12
N2 - Despite the high incidence and prognostic relevance of hemorrhagic shock and abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver lobe using a four-edged scalpel and subsequent liver packing), and pressure-controlled hemorrhagic shock with a mean arterial pressure of 30 ± 5 mmHg (a maximum of 45% of the total blood volume). The combined traumatic insult led to severe signs of hemorrhagic shock and impaired pulmonary function. In conclusion, a consistent, reproducible, and clinically relevant porcine model of multisystem injury with controlled (pressure-controlled blood withdrawal) and uncontrolled components of hemorrhage (liver laceration) with the potential for rebleeding was established.
AB - Despite the high incidence and prognostic relevance of hemorrhagic shock and abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver lobe using a four-edged scalpel and subsequent liver packing), and pressure-controlled hemorrhagic shock with a mean arterial pressure of 30 ± 5 mmHg (a maximum of 45% of the total blood volume). The combined traumatic insult led to severe signs of hemorrhagic shock and impaired pulmonary function. In conclusion, a consistent, reproducible, and clinically relevant porcine model of multisystem injury with controlled (pressure-controlled blood withdrawal) and uncontrolled components of hemorrhage (liver laceration) with the potential for rebleeding was established.
KW - Abdominal Injuries/complications
KW - Animals
KW - Disease Models, Animal
KW - Lung/metabolism
KW - Respiratory Function Tests
KW - Shock, Hemorrhagic/complications
KW - Swine
KW - Thoracic Injuries/complications
U2 - 10.1097/SHK.0b013e3182709c90
DO - 10.1097/SHK.0b013e3182709c90
M3 - Article
C2 - 23042201
SN - 1073-2322
VL - 38
SP - 664
EP - 670
JO - Shock
JF - Shock
IS - 6
ER -