@article{9f9d96c68b8842b5a17c7a3638dbb554,
title = "In vitro digestion of starches in a dynamic gastrointestinal model: an innovative study to optimize dietary management of patients with hepatic glycogen storage diseases",
abstract = "Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD-patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro model. The following brands of UCCS were studied: Argo and Great Value from the United States of America; Brazilian Maizena Duryea and Yoki from Brazil; Dutch Maizena Duryea from the Netherlands. Glycosade, a modified starch, and sweet polvilho, a Brazilian starch extracted from cassava, were also studied. The starch fractions were analyzed by glycemic TNO index method and digestion analyses were determined by the TIM-1 system, a dynamic, computer-controlled, in vitro gastrointestinal model, which simulates the stomach and small intestine. The final digested amounts were between 84 and 86% for the UCCS and Glycosade, but was 75.5% for sweet povilho. At 180 min of the experiment, an important time-point for GSD patients, the digested amount of the starches corresponded to 67.9-71.5 for the UCCS and Glycosade, while it was 55.5% for sweet povilho. In an experiment with a mixture of sweet polvilho and Brazilian Maizena Duryea, a final digested amount of 78.4% was found, while the value at 180 min was 61.7%. Sweet polvilho seems to have a slower and extended release of glucose and looks like an interesting product to be further studied as it might lead to extended normoglycemia in GSD-patients.",
keywords = "UNCOOKED CORNSTARCH, GLYCEMIC RESPONSE, CLINICAL COURSE, HEALTHY-MEN, DIGESTIBILITY, THERAPY, GLUCOSE, IA, INTESTINE, PRODUCTS",
author = "T. Nalin and K. Venema and D.A. Weinstein and {de Souza}, C.F. and I.D. Perry and {van Wandelen}, M.T. and {van Rijn}, M. and G.P. Smit and I.V. Schwartz and T.G. Derks",
year = "2015",
month = may,
doi = "10.1007/s10545-014-9763-y",
language = "English",
volume = "38",
pages = "529--536",
journal = "Journal of Inherited Metabolic Disease",
issn = "0141-8955",
publisher = "Wiley",
number = "3",
}