In vitro digestion of starches in a dynamic gastrointestinal model: an innovative study to optimize dietary management of patients with hepatic glycogen storage diseases

T. Nalin, K. Venema, D.A. Weinstein, C.F. de Souza, I.D. Perry, M.T. van Wandelen, M. van Rijn, G.P. Smit, I.V. Schwartz, T.G. Derks

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4 Citations (Scopus)

Abstract

Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD-patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro model. The following brands of UCCS were studied: Argo and Great Value from the United States of America; Brazilian Maizena Duryea and Yoki from Brazil; Dutch Maizena Duryea from the Netherlands. Glycosade, a modified starch, and sweet polvilho, a Brazilian starch extracted from cassava, were also studied. The starch fractions were analyzed by glycemic TNO index method and digestion analyses were determined by the TIM-1 system, a dynamic, computer-controlled, in vitro gastrointestinal model, which simulates the stomach and small intestine. The final digested amounts were between 84 and 86% for the UCCS and Glycosade, but was 75.5% for sweet povilho. At 180 min of the experiment, an important time-point for GSD patients, the digested amount of the starches corresponded to 67.9-71.5 for the UCCS and Glycosade, while it was 55.5% for sweet povilho. In an experiment with a mixture of sweet polvilho and Brazilian Maizena Duryea, a final digested amount of 78.4% was found, while the value at 180 min was 61.7%. Sweet polvilho seems to have a slower and extended release of glucose and looks like an interesting product to be further studied as it might lead to extended normoglycemia in GSD-patients.
Original languageEnglish
Pages (from-to)529-536
Number of pages8
JournalJournal of Inherited Metabolic Disease
Volume38
Issue number3
DOIs
Publication statusPublished - May 2015

Keywords

  • UNCOOKED CORNSTARCH
  • GLYCEMIC RESPONSE
  • CLINICAL COURSE
  • HEALTHY-MEN
  • DIGESTIBILITY
  • THERAPY
  • GLUCOSE
  • IA
  • INTESTINE
  • PRODUCTS

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