TY - JOUR
T1 - Thrombo-Inflammation in Cardiovascular Disease
T2 - An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis
AU - d'Alessandro, Elisa
AU - Becker, Christian
AU - Bergmeier, Wolfgang
AU - Bode, Christoph
AU - Bourne, Joshua H.
AU - Brown, Helena
AU - Buller, Harry R.
AU - ten Cate-Hoek, Arina J.
AU - ten Cate, Vincent
AU - van Cauteren, Yvonne J. M.
AU - Cheung, Yam F. H.
AU - Cleuren, Audrey
AU - Coenen, Danielle
AU - Crijns, Harry J. G. M.
AU - de Simone, Ilaria
AU - Dolleman, Sophie C.
AU - Klein, Christine Espinola
AU - Fernandez, Delia I.
AU - Granneman, Lianne
AU - van t Hof, Arnoud
AU - Henke, Peter
AU - Henskens, Yvonne M. C.
AU - Huang, Jingnan
AU - Jennings, Lisa K.
AU - Jooss, Natalie
AU - Karel, Mieke
AU - van den Kerkhof, Danique
AU - Klok, Frederik A.
AU - Kremers, Bram
AU - Laemmle, Bernhard
AU - Leader, Avi
AU - Lundstrom, Annika
AU - Mackman, Nigel
AU - Mannucci, Pier M.
AU - Maqsood, Zahra
AU - van der Meijden, Paola E. J.
AU - van Moorsel, Marc
AU - Moran, Luis A,
AU - van Mourik, Manouk
AU - Navarro, Stefano
AU - Neagoe, Raluca A. I.
AU - Olie, Renske H.
AU - van Paridon, Pauline
AU - Posma, Jens
AU - Provenzale, Isabella
AU - Reitsma, P.H.
AU - Scaf, Billy
AU - Schurgers, Leon
AU - Seelig, Jaap
AU - Siegbahn, Agneta
AU - Siegerink, Bob
AU - Soehnlein, Oliver
AU - Soriano, Eva Maria
AU - Sowa, Marcin A.
AU - Spronk, Henri M. H.
AU - Storey, Robert F.
AU - Tantiwong, Chukiat
AU - Veninga, Alicia
AU - Wang, Xueqing
AU - Watson, Steve P.
AU - Weitz, Jeffrey
AU - Zeerleder, Sacha
AU - ten Cate, Hugo
AU - Scientific Reviewer Committee
N1 - Funding Information:
This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 766118.” E.D., S.C.D., and B.S. are supported by a grant from the Netherlands Heart Foundation (CVON2014–09, RACE V, reappraisal of AF: interaction between hypercoagulability, electrical remodeling, and vascular destabilization in the progression of AF).
Publisher Copyright:
© 2020 Georg Thieme Verlag KG Stuttgart New York.
PY - 2020/4/14
Y1 - 2020/4/14
N2 - Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
AB - Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
KW - thrombosis
KW - inflammation
KW - coagulation
KW - pulmonary embolism
KW - myocardial infarction
KW - stroke
KW - platelets
KW - ACTIVATABLE FIBRINOLYSIS INHIBITOR
KW - DEEP-VEIN THROMBOSIS
KW - PERIPHERAL ARTERY-DISEASE
KW - ACUTE CORONARY SYNDROMES
KW - NEUTROPHIL EXTRACELLULAR TRAPS
KW - SUBCLINICAL LEAFLET THROMBOSIS
KW - CATHETER-DIRECTED THROMBOLYSIS
KW - ISCHEMIA-REPERFUSION INJURY
KW - VENOUS THROMBOSIS
KW - TISSUE FACTOR
U2 - 10.1055/s-0040-1708035
DO - 10.1055/s-0040-1708035
M3 - Article
C2 - 32289858
SN - 0340-6245
VL - 120
SP - 538
EP - 564
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 4
ER -