Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Elisa d'Alessandro, Christian Becker, Wolfgang Bergmeier, Christoph Bode, Joshua H. Bourne, Helena Brown, Harry R. Buller, Arina J. ten Cate-Hoek, Vincent ten Cate, Yvonne J. M. van Cauteren, Yam F. H. Cheung, Audrey Cleuren, Danielle Coenen, Harry J. G. M. Crijns, Ilaria de Simone, Sophie C. Dolleman, Christine Espinola Klein, Delia I. Fernandez, Lianne Granneman, Arnoud van t HofPeter Henke, Yvonne M. C. Henskens, Jingnan Huang, Lisa K. Jennings, Natalie Jooss, Mieke Karel, Danique van den Kerkhof, Frederik A. Klok, Bram Kremers, Bernhard Laemmle, Avi Leader, Annika Lundstrom, Nigel Mackman, Pier M. Mannucci, Zahra Maqsood, Paola E. J. van der Meijden, Marc van Moorsel, Luis A, Moran, Manouk van Mourik, Stefano Navarro, Raluca A. I. Neagoe, Renske H. Olie, Pauline van Paridon, Jens Posma, Isabella Provenzale, P.H. Reitsma, Billy Scaf, Leon Schurgers, Jaap Seelig, Agneta Siegbahn, Bob Siegerink, Oliver Soehnlein, Eva Maria Soriano, Marcin A. Sowa, Henri M. H. Spronk, Robert F. Storey, Chukiat Tantiwong, Alicia Veninga, Xueqing Wang, Steve P. Watson, Jeffrey Weitz, Sacha Zeerleder, Hugo ten Cate*, Scientific Reviewer Committee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

Original languageEnglish
Pages (from-to)538-564
Number of pages27
JournalThrombosis and Haemostasis
Volume120
Issue number4
DOIs
Publication statusPublished - 14 Apr 2020

Keywords

  • thrombosis
  • inflammation
  • coagulation
  • pulmonary embolism
  • myocardial infarction
  • stroke
  • platelets
  • ACTIVATABLE FIBRINOLYSIS INHIBITOR
  • DEEP-VEIN THROMBOSIS
  • PERIPHERAL ARTERY-DISEASE
  • ACUTE CORONARY SYNDROMES
  • NEUTROPHIL EXTRACELLULAR TRAPS
  • SUBCLINICAL LEAFLET THROMBOSIS
  • CATHETER-DIRECTED THROMBOLYSIS
  • ISCHEMIA-REPERFUSION INJURY
  • VENOUS THROMBOSIS
  • TISSUE FACTOR

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