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Aaron Isaacs

 https://orcid.org/0000-0001-5037-4834
20102024

Research activity per year

  • 122 Article
  • 5 Comment/Letter to the editor
  • 3 Erratum / corrigendum / retractions
  • 1 (Systematic) Review article
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Search results

  • 2016

    Association of the IGF1 gene with fasting insulin levels

    Willems, S. M., Cornes, B. K., Brody, J. A., Morrison, A. C., Lipovich, L., Dauriz, M., Chen, Y., Liu, C-T., Rybin, D. V., Gibbs, R. A., Muzny, D., Pankow, J. S., Psaty, B. M., Boerwinkle, E., Rotter, J. I., Siscovick, D. S., Vasan, R. S., Kaplan, R. C., Isaacs, A., Dupuis, J., & 2 othersvan Duijn, C. M. & Meigs, J. B., Sept 2016, In: European Journal of Human Genetics. 24, 9, p. 1337-1343

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

    Iotchkova, V., Huang, J., Morris, J. A., Jain, D., Barbieri, C., Walter, K., Min, J. L., Chen, L., Astle, W., Cocca, M., Deelen, P., Elding, H., Farmaki, A-E., Franklin, C. S., Franberg, M., Gaunt, T. R., Hofman, A., Jiang, T., Kleber, M. E., Lachance, G., & 47 othersLuan, J., Malerba, G., Matchan, A., Mead, D., Memari, Y., Ntalla, I., Panoutsopoulou, K., Pazoki, R., Perry, J. R. B., Rivadeneira, F., Sabater-Lleal, M., Sennblad, B., Shin, S-Y., Southam, L., Traglia, M., van Dijk, F., van Leeuwen, E. M., Zaza, G., Zhang, W., Amin, N., Butterworth, A., Chambers, J. C., Dedoussis, G., Dehghan, A., Franco, O. H., Franke, L., Frontini, M., Gambaro, G., Gasparini, P., Hamsten, A., Issacs, A., Kooner, J. S., Kooperberg, C., Langenberg, C., Marz, W., Scott, R. A., Swertz, M. A., Toniolo, D., Uitterlinden, A. G., van Duijn, C. M., Watkins, H., Zeggini, E., Maurano, M. T., Timpson, N. J., Reiner, A. P., Auer, P. L. & Soranzo, N., Nov 2016, In: Nature Genetics. 48, 11, p. 1303-1312

    Research output: Contribution to journal › Article › Academic › peer-review

  • Discriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes

    Jainandunsing, S., Wattimena, J. L. D., Verhoeven, A. J. M., Langendonk, J. G., Rietveld, T., Isaacs, A. J., Sijbrands, E. J. G. & de Rooij, F. W. M., 1 Apr 2016, In: Metabolic syndrome and related disorders. 14, 3, p. 175-181

    Research output: Contribution to journal › Article › Academic › peer-review

  • Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

    Evans, D. S., Avery, C. L., Nalls, M. A., Li, G., Barnard, J., Smith, E. N., Tanaka, T., Butler, A. M., Buxbaum, S. G., Alonso, A., Arking, D. E., Berenson, G. S., Bis, J. C., Buyske, S., Carty, C. L., Chen, W., Chung, M. K., Cummings, S. R., Deo, R., Eaton, C. B., & 41 othersFox, E. R., Heckbert, S. R., Heiss, G., Hindorff, L. A., Hsueh, W-C., Isaacs, A., Jamshidi, Y., Kerr, K. F., Liu, F., Liu, Y., Lohman, K. K., Magnani, J. W., Maher, J. F., Mehra, R., Meng, Y. A., Musani, S. K., Newton-Cheh, C., North, K. E., Psaty, B. M., Redline, S., Rotter, J. I., Schnabel, R. B., Schork, N. J., Shohet, R. V., Singleton, A. B., Smith, J. D., Soliman, E. Z., Srinivasan, S. R., Taylor, H. A. . J., Van Wagoner, D. R., Wilson, J. G., Young, T., Zhang, Z-M., Zonderman, A. B., Evans, M. K., Ferrucci, L., Murray, S. S., Tranah, G. J., Whitsel, E. A., Reiner, A. P. & Sotoodehnia, N., 1 Oct 2016, In: Human Molecular Genetics. 25, 19, p. 4350-4368

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M-H., Pers, T. H., Johnson, A. D., Ko, Y-A., Fuchsberger, C., Tayo, B., & 31 othersNalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., d'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., van der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, A., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Kraemer, B. K. & Author collaboration, Jan 2016, In: Nature Communications. 7, 19 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genetic variants in RBFOX3 are associated with sleep latency

    Amin, N., Allebrandt, K. V., van der Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, F. M., Byrne, E. M., Oole, E., Kolcic, I., Chen, T-H., Evans, D. S., Coresh, J., Vogelzangs, N., & 54 othersKarjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K. D., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H-E., Müller-Nurasyid, M., Fehrmann, R. S., Montgomery, G. W., Hofman, A., Kao, W. H. L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van IJcken, W. F., Penninx, B. W., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., Oct 2016, In: European Journal of Human Genetics. 24, 10, p. 1488-1495 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

    Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M-H., Chen, T. C., Chen, Y-D. I., Chung, J., Miglianico, F. D. G., Eriksson, J., Ferrucci, L., Friedrich, N., & 66 othersGnewuch, C., Goodarzi, M. O., Grarup, N., Guo, T., Hammer, E., Hayes, R. B., Hicks, A. A., Hofman, A., Houwing-Duistermaat, J. J., Hu, F., Hunter, D. J., Husemoen, L. L., Isaacs, A., Jacobs, K. B., Janssen, J. A. M. J. L., Jansson, J-O., Jehmlich, N., Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T. O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R. J. F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellstrom, D., Nauck, M., Newman, A. B., Pollak, M. N., Pramstaller, P. P., Prokopenko, I., Psaty, B. M., Reincke, M., Rimm, E. B., Rotter, J. I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjogren, K., Slagboom, P. E., Strickler, H. D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Toenjes, A., Uh, H-W., van Duijn, C. M., van Heemst, D., Vandenput, L., Vasan, R. S., Voelker, U., Willems, S. M., Ohlsson, C., Wallaschofski, H. & Kaplan, R. C., Oct 2016, In: Aging Cell. 15, 5, p. 811-824

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

    Kilpelainen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, A. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikainen, L-P., Eriksson, J., & 157 othersHenneman, P., Lahti, J., Tanaka, T., Luan, J., Del Greco M, F., Pasko, D., Renstrom, F., Willems, S. M., Mahajan, A., Rose, L. M., Guo, X., Liu, Y., Kleber, M. E., Perusse, L., Gaunt, T., Ahluwalia, T. S., Sung, Y. J., Ramos, Y. F., Amin, N., Amuzu, A., Barroso, I., Bellis, C., Blangero, J., Buckley, B. M., Bohringer, S., Chen, Y-D. I., de Craen, A. J. N., Crosslin, D. R., Dale, C. E., Dastani, Z., Day, F. R., Deelen, J., Delgado, G. E., Demirkan, A., Finucane, F. M., Ford, I., Garcia, M. E., Gieger, C., Gustafsson, S., Hallmans, G., Hankinson, S. E., Havulinna, A. S., Herder, C., Hernandez, D., Hicks, A. A., Hunter, D. J., Illig, T., Ingelsson, E., Ioan-Facsinay, A., Jansson, J-O., Jenny, N. S., Jorgensen, M. E., Jorgensen, T., Karlsson, M., Koenig, W., Kraft, P., Kwekkeboom, J., Laatikainen, T., Ladwig, K-H., LeDuc, C. A., Lowe, G., Lu, Y., Marques-Vidal, P., Meisinger, C., Menni, C., Morris, A. P., Myers, R. H., Mannisto, S., Nalls, M. A., Paternoster, L., Peters, A., Pradhan, A. D., Rankinen, T., Rasmussen-Torvik, L. J., Rathmann, W., Rice, T. K., Richards, J. B., Ridker, P. M., Sattar, N., Savage, D. B., Soderberg, S., Timpson, N. J., Vandenput, L., van Heemst, D., Uh, H-W., Vohl, M-C., Walker, M., Wichmann, H-E., Widen, E., Wood, A. R., Yao, J., Zeller, T., Zhang, Y., Meulenbelt, I., Kloppenburg, M., Astrup, A., Sorensen, T. I. A., Sarzynski, M. A., Rao, D. C., Jousilahti, P., Vartiainen, E., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Kajantie, E., Osmond, C., Palotie, A., Eriksson, J. G., Heliovaara, M., Knekt, P. B., Koskinen, S., Jula, A., Perola, M., Huupponen, R. K., Viikari, J. S., Kahonen, M., Lehtimaki, T., Raitakari, O. T., Mellstrom, D., Lorentzon, M., Casas, J. P., Bandinelli, S., Maerz, W., Isaacs, A., van Dijk, K. W., van Duijn, C. M., Harris, T. B., Bouchard, C., Allison, M. A., Chasman, D. I., Ohlsson, C., Lind, L., Scott, R. A., Langenberg, C., Wareham, N. J., Ferrucci, L., Frayling, T. M., Pramstaller, P. P., Borecki, I. B., Waterworth, D. M., Bergmann, S., Waeber, G., Vollenweider, P., Vestergaard, H., Hansen, T., Pedersen, O., Hu, F. B., Slagboom, P. E., Grallert, H., Spector, T. D., Jukema, J. W., Klein, R. J., Schadt, E. E., Franks, P. W., Lindgren, C. M., Leibel, R. L. & Loos, R. J. F., Feb 2016, In: Nature Communications. 7, 10494.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

    van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E., & 78 othersLyytikainen, L-P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyj, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S-T., de Geus, E. J., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J. M., de Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kahonen, M., Lehtimaki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M., Ripatti, S., van Dijk, K. W., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A. & van Duijn, C. M., Jul 2016, In: Journal of Medical Genetics. 53, 7, p. 441-449

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

    Natarajan, P., Bis, J. C., Bielak, L. F., Cox, A. J., Dorr, M., Feitosa, M. F., Franceschini, N., Guo, X., Hwang, S-J., Isaacs, A., Jhun, M. A., Kavousi, M., Li-Gao, R., Lyytikainen, L-P., Marioni, R. E., Schminke, U., Stitziel, N. O., Tada, H., van Setten, J., Smith, A. V., & 80 othersVojinovic, D., Yanek, L. R., Yao, J., Yerges-Armstrong, L. M., Amin, N., Baber, U., Borecki, I. B., Carr, J. J., Chen, Y-D. I., Cupples, L. A., de Jong, P. A., de Koning, H., de Vos, B. D., Demirkan, A., Fuster, V., Franco, O. H., Goodarzi, M. O., Harris, T. B., Heckbert, S. R., Heiss, G., Hoffmann, U., Hofman, A., Isgum, I., Jukema, J. W., Kahonen, M., Kardia, S. L. R., Kral, B. G., Launer, L. J., Massaro, J., Mehran, R., Mitchell, B. D., Jr, T. H. M., de Mutsert, R., Newman, A. B., Nguyen, K., North, K. E., O'Connell, J. R., Oudkerk, M., Pankow, J. S., Peloso, G. M., Post, W., Province, M. A., Raffield, L. M., Raitakari, O. T., Reilly, D. F., Rivadeneira, F., Rosendaal, F., Sartori, S., Taylor, K. D., Teumer, A., Trompet, S., Turner, S. T., Uitterlinden, A. G., Vaidya, D., van der Lugt, A., Volker, U., Wardlaw, J. M., Wassel, C. L., Weiss, S., Wojczynski, M. K., Becker, D. M., Becker, L. C., Boerwinkle, E., Bowden, D. W., Deary, I. J., Dehghan, A., Felix, S. B., Gudnason, V., Lehtimaki, T., Mathias, R., Mook-Kanamori, D. O., Psaty, B. M., Rader, D. J., Rotter, J. I., Wilson, J. G., van Duijn, C. M., Volzke, H., Kathiresan, S., Peyser, P. A. & O'Donnell, C. J., Dec 2016, In: Circulation : Cardiovascular Genetics. 9, 6, p. 511-520

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

    Ricano-Ponce, I., Zhernakova, D. V., Deelen, P., Luo, O., Li, X., Isaacs, A., Karjalainen, J., Di Tommaso, J., Borek, Z. A., Zorro, M. M., Gutierrez-Achury, J., Uitterlinden, A. G., Hofman, A., van Meurs, J., Netea, M. G., Jonkers, I. H., Withoff, S., van Duijn, C. M., Li, Y., Ruan, Y., & 3 othersFranke, L., Wijmenga, C. & Kumar, V., Apr 2016, In: Journal of Autoimmunity. 68, p. 62-74

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

    Demirkan, A., Lahti, J., Direk, N., Viktorin, A., Lunetta, K. L., Terracciano, A., Nalls, M. A., Tanaka, T., Hek, K., Fornage, M., Wellmann, J., Cornelis, M. C., Ollila, H. M., Yu, L., Smith, J. A., Pilling, L. C., Isaacs, A., Palotie, A., Zhuang, W. V., Zonderman, A., & 37 othersFaul, J. D., Sutin, A., Meirelles, O., Mulas, A., Hofman, A., Uitterlinden, A., Rivadeneira, F., Perola, M., Zhao, W., Salomaa, V., Yaffe, K., Luik, A. I., Liu, Y., Ding, J., Lichtenstein, P., Landen, M., Widen, E., Weir, D. R., Llewellyn, D. J., Murray, A., Kardia, S. L. R., Eriksson, J. G., Koenen, K., Magnusson, P. K. E., Ferrucci, L., Mosley, T. H., Cucca, F., Oostra, B. A., Bennett, D. A., Paunio, T., Berger, K., Harris, T. B., Pedersen, N. L., Murabito, J. M., Tiemeier, H., van Duijn, C. M. & Raeikkoenen, K., Jun 2016, In: Psychological Medicine. 46, 8, p. 1613-1623

    Research output: Contribution to journal › Article › Academic › peer-review

  • Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram

    Verweij, N., Leach, I. M., Isaacs, A., Arking, D. E., Bis, J. C., Pers, T. H., Van den Berg, M. E., Lyytikainen, L-P., Barnett, P., Wang, X., Soliman, E. Z., Van Duijn, C. M., Kahonen, M., Van Veldhuisen, D. J., Kors, J. A., Raitakari, O. T., Silva, C. T., Lehtimaki, T., Hillege, H. L., Hirschhorn, J. N., & 9 othersBoyer, L. A., Van Gilst, W. H., Alonso, A., Sotoodehnia, N., Eijgelsheim, M., De Boer, R. A., De Bakker, P. I. W., Franke, L. & Van der Harst, P., 15 May 2016, In: Human Molecular Genetics. 25, 10, p. 2093-2103

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2015

    CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease

    WiN Study Group, Jun 2015, In: Journal of Thrombosis and Haemostasis. 13, 6, p. 956-66 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
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  • Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

    ENGAGE Consortium, Jul 2015, In: Plos Genetics. 11, 7, e1005230.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes

    Jainandunsing, S., Özcan, B., Rietveld, T., van Miert, J. N. I., Isaacs, A. J., Langendonk, J. G., de Rooij, F. W. M. & Sijbrands, E. J. G., Feb 2015, In: Acta Diabetologica. 52, 1, p. 11-9 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

    van Leeuwen, E. M., Huffman, J. E., Bis, J. C., Isaacs, A., Mulder, M., Sabo, A., Smith, A. V., Demissie, S., Manichaikul, A., Brody, J. A., Feitosa, M. F., Duan, Q., Schraut, K. E., Navarro, P., van Vliet-Ostaptchouk, J. V., Zhu, G., Mbarek, H., Trompet, S., Verweij, N., Lyytikäinen, L-P., & 32 othersDeelen, J., Nolte, I. M., van der Laan, S. W., Davies, G., Vermeij-Verdoold, A. J., van Oosterhout, A. A., Vergeer-Drop, J. M., Arking, D. E., Trochet, H., Medina-Gomez, C., Rivadeneira, F., Uitterlinden, A. G., Dehghan, A., Franco, O. H., Sijbrands, E. J., Hofman, A., White, C. C., Mychaleckyj, J. C., Peloso, G. M., Swertz, M. A., Willemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W., Ford, I., Buckley, B. M., de Craen, A. J., Starr, J. M., Deary, I. J., Pasterkamp, G., Generation Scotland & van Duijn, C., 2015, In: NPJ aging and mechanisms of disease. 1, p. 15011

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genetic studies of body mass index yield new insights for obesity biology

    Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J. C., Winkler, T. W., & 34 othersWood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Zhao, J. H., Zhao, W., Chen, J., Fehrmann, R., Hedman, Å. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Deng, G., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Goel, A., Gong, J., Jackson, A. U., Isaacs, A., Wong, A., Jacobs, K. B., LifeLines Cohort Study, Hirschorn, J. N., Loos, R. J. F. & Speliotes, E. K., 12 Feb 2015, In: Nature. 518, 7538, p. 197-206 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

    van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D. J., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., van Dijk, F., & 32 othersWillemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J. M., Uh, H-W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Genome of the Netherlands Consortium & van Duijn, C., 9 Mar 2015, In: Nature Communications. 6, p. 6065

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

    Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A-K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J. M., van Leeuwen, E. M., Amin, N., & 28 othersDharuri, H., Westra, H-J., Franke, L., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, D. R., Whitfield, J. B., Penninx, B. W., Spector, T. D., Metspalu, A., Slagboom, P. E., van Dijk, K. W., 't Hoen, P. A. C., Strauch, K., Martin, N. G., van Ommen, G-J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., van Duijn, C. M. & Boomsma, D. I., 12 Jun 2015, In: Nature Communications. 6, p. 7208

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

    Silva, C. T., Kors, J. A., Amin, N., Dehghan, A., Witteman, J. C. M., Willemsen, R., Oostra, B. A., van Duijn, C. M. & Isaacs, A., Nov 2015, In: Human Genetics. 134, 11-12, p. 1211-1219 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

    Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M-F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S., & 31 othersStančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Stoiber, M. H., Strawbridge, R. J., Taylor, K. D., Varga, T. V., Allin, K. H. & EPIC-InterAct Consortium, 29 Jan 2015, In: Nature Communications. 6, p. 5897

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • New genetic loci link adipose and insulin biology to body fat distribution

    Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., Strawbridge, R. J., Pers, T. H., Fischer, K., Justice, A. E., Workalemahu, T., Wu, J. M. W., Buchkovich, M. L., Heard-Costa, N. L., Roman, T. S., Drong, A. W., Song, C., Gustafsson, S., Day, F. R., Esko, T., & 33 othersFall, T., Kutalik, Z., Luan, J., Randall, J. C., Scherag, A., Vedantam, S., Wood, A. R., Chen, J., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C-T., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Ehret, G. B., Feitosa, M. F., Goel, A., Jackson, A. U., Johnson, T., Kleber, M. E., Kristiansson, K., Isaacs, A., Wong, A., Staessen, J. A., ADIPOGen Consortium, Lindgren, C. M. & Mohlke, K. L., 12 Feb 2015, In: Nature. 518, 7538, p. 187-196 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • The impact of low-frequency and rare variants on lipid levels

    Surakka, I., Horikoshi, M., Mägi, R., Sarin, A-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hägg, S., Hottenga, J-J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T., & 32 othersRied, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H-J., Blades, M., de Craen, A. J. M., de Geus, E. J., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hyppönen, E., Karssen, L. C., Lehtimäki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Müller-Nurasyid, M., Mpindi, J-P., Pedersen, N. L., Penninx, B. W. J. H., Perola, M., Pers, T. H., Peters, A., Rung, J., Smit, J. H., Steinthorsdottir, V., ENGAGE Consortium & Ripatti, S., Jun 2015, In: Nature Genetics. 47, 6, p. 589-97 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

    Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Leach, I. M., Drong, A. W., Abbott, J., Wahl, S., Tan, S-T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. S., Bonder, M. J., & 31 othersChen, P., Dehghan, A., Edwards, T. L., Esko, T., Go, M. J., Harris, S. E., Hartiala, J., Kasela, S., Kasturiratne, A., Khor, C-C., Kleber, M. E., Li, H., Mok, Z. Y., Nakatochi, M., Sapari, N. S., Saxena, R., Stewart, A. F. R., Stolk, L., Tabara, Y., Teh, A. L., Wu, Y., Wu, J-Y., Zhang, Y., Aits, I., Alves, A. D. S. C., Das, S., Dorajoo, R., Isaacs, A., Wolffenbuttel, B. H. W., Kleinjans, J. C. S. & Author collaboration, Nov 2015, In: Nature Genetics. 47, 11, p. 1282–1293 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • 2014

    A metabolomic profile is associated with the risk of incident coronary heart disease

    Vaarhorst, A. A. M., Verhoeven, A., Weller, C. M., Böhringer, S., Göraler, S., Meissner, A., Deelder, A. M., Henneman, P., Gorgels, A. P. M., van den Brandt, P. A., Schouten, L. J., van Greevenbroek, M. M., Merry, A. H. H., Verschuren, W. M. M., van den Maagdenberg, A. M. J. M., van Dijk, K. W., Isaacs, A., Boomsma, D., Oostra, B. A., van Duijn, C. M., & 5 othersJukema, J. W., Boer, J. M. A., Feskens, E., Heijmans, B. T. & Slagboom, P. E., 1 Jan 2014, In: American Heart Journal. 168, 1, p. 45-52.e7

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

    Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., Smith, A. V., & 32 othersGrove, M. L., Zanoni, P., Redon, V., Demissie, S., Lawson, K., Peters, U., Carlson, C., Jackson, R. D., Ryckman, K. K., Mackey, R. H., Robinson, J. G., Siscovick, D. S., Schreiner, P. J., Mychaleckyj, J. C., Pankow, J. S., Hofman, A., Uitterlinden, A. G., Harris, T. B., Taylor, K. D., Stafford, J. M., Reynolds, L. M., Marioni, R. E., Dehghan, A., Franco, O. H., Patel, A. P., Lu, Y., Hindy, G., Gottesman, O., Bottinger, E. P., Melander, O., NHLBI GO Exome Sequencing Project & Cupples, L. A., 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 223-32 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., Chu, A. Y., Estrada, K., Luan, J., Kutalik, Z., Amin, N., Buchkovich, M. L., Croteau-Chonka, D. C., Day, F. R., Duan, Y., Fall, T., Fehrmann, R., Ferreira, T., Jackson, A. U., Karjalainen, J., & 34 othersLo, K. S., Locke, A. E., Mägi, R., Mihailov, E., Porcu, E., Randall, J. C., Scherag, A., Vinkhuyzen, A. A. E., Westra, H-J., Winkler, T. W., Workalemahu, T., Zhao, J. H., Absher, D., Albrecht, E., Anderson, D., Baron, J., Beekman, M., Demirkan, A., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Fraser, R. M., Goel, A., Gong, J., Justice, A. E., Kanoni, S., Isaacs, A., Wong, A., Jacobs, K. B., Electronic Medical Records and Genomics (eMERGE) Consortium, Visscher, P. M., Hirschhorn, J. N. & Frayling, T. M., Nov 2014, In: Nature Genetics. 46, 11, p. 1173-86 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

    Avery, C. L., Sitlani, C. M., Arking, D. E., Arnett, D. K., Bis, J. C., Boerwinkle, E., Buckley, B. M., Ida Chen, Y-D., de Craen, A. J. M., Eijgelsheim, M., Enquobahrie, D., Evans, D. S., Ford, I., Garcia, M. E., Gudnason, V., Harris, T. B., Heckbert, S. R., Hochner, H., Hofman, A., Hsueh, W-C., & 34 othersIsaacs, A., Jukema, J. W., Knekt, P., Kors, J. A., Krijthe, B. P., Kristiansson, K., Laaksonen, M., Liu, Y., Li, X., Macfarlane, P. W., Newton-Cheh, C., Nieminen, M. S., Oostra, B. A., Peloso, G. M., Porthan, K., Rice, K., Rivadeneira, F. F., Rotter, J. I., Salomaa, V., Sattar, N., Siscovick, D. S., Slagboom, P. E., Smith, A. V., Sotoodehnia, N., Stott, D. J., Stricker, B. H., Stürmer, T., Trompet, S., Uitterlinden, A. G., van Duijn, C., Westendorp, R. G. J., Witteman, J. C., Whitsel, E. A. & Psaty, B. M., Feb 2014, In: Pharmacogenomics Journal. 14, 1, p. 6-13 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

    Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., Gho, J. M. I. H., & 116 othersGieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Mateo Leach, I., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., van der Most, P. J., Van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-DeHoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., M Ridker, P., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., FitzGerald, G. A., Gums, J. G., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., de Bakker, P. I. W., Levy, D., Asselbergs, F. W., Munroe, P. B. & Keating, B. J., 6 Mar 2014, In: American Journal of Human Genetics. 94, 3, p. 349-60 12 p.

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    Open Access

  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dörr, M., Müller-Nurasyid, M., Lahtinen, A. M., & 32 othersNolte, I. M., Smith, A. V., Bis, J. C., Isaacs, A., Newhouse, S. J., Evans, D. S., Post, W. S., Waggott, D., Lyytikäinen, L-P., Hicks, A. A., Eisele, L., Ellinghaus, D., Hayward, C., Navarro, P., Ulivi, S., Tanaka, T., Tester, D. J., Chatel, S., Gustafsson, S., Kumari, M., Morris, R. W., Naluai, Å. T., Padmanabhan, S., Kluttig, A., Strohmer, B., Panayiotou, A. G., Torres, M., Knoflach, M., Hubacek, J. A., den Hoed, M., CARe Consortium & Newton-Cheh, C. H., Aug 2014, In: Nature Genetics. 46, 8, p. 826-36 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

    Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., Luan, J., Kutalik, Z., Sanna, S., van der Meer, P., Tanaka, T., Wang, F., Westra, H-J., Franke, L., Mihailov, E., Milani, L., & 32 othersHälldin, J., Häldin, J., Winkelmann, J., Meitinger, T., Thiery, J., Peters, A., Waldenberger, M., Rendon, A., Jolley, J., Sambrook, J., Kiemeney, L. A., Sweep, F. C., Sala, C. F., Schwienbacher, C., Pichler, I., Hui, J., Demirkan, A., Isaacs, A., Amin, N., Steri, M., Waeber, G., Verweij, N., Powell, J. E., Nyholt, D. R., Heath, A. C., Madden, P. A. F., Visscher, P. M., Wright, M. J., Montgomery, G. W., Martin, N. G., InterAct Consortium & Whitfield, J. B., 29 Oct 2014, In: Nature Communications. 5, p. 4926

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

    Pop, A. S., Levenga, J., de Esch, C. E. F., Buijsen, R. A. M., Nieuwenhuizen, I. M., Li, T., Isaacs, A., Gasparini, F., Oostra, B. A. & Willemsen, R., Mar 2014, In: Psychopharmacology. 231, 6, p. 1227-35 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels

    van Leeuwen, E. M., Smouter, F. A. S., Kam-Thong, T., Karbalai, N., Smith, A. V., Harris, T. B., Launer, L. J., Sitlani, C. M., Li, G., Brody, J. A., Bis, J. C., White, C. C., Jaiswal, A., Oostra, B. A., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Boerwinkle, E., Ballantyne, C. M., Gudnason, V., & 8 othersPsaty, B. M., Cupples, L. A., Järvelin, M-R., Ripatti, S., Isaacs, A., Müller-Myhsok, B., Karssen, L. C. & van Duijn, C. M., 2014, In: PLOS ONE. 9, 10, p. e109290

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

    Lange, L. A., Hu, Y., Zhang, H., Xue, C., Schmidt, E. M., Tang, Z-Z., Bizon, C., Lange, E. M., Smith, J. D., Turner, E. H., Jun, G., Kang, H. M., Peloso, G., Auer, P., Li, K-P., Flannick, J., Zhang, J., Fuchsberger, C., Gaulton, K., Lindgren, C., & 31 othersLocke, A., Manning, A., Sim, X., Rivas, M. A., Holmen, O. L., Gottesman, O., Lu, Y., Ruderfer, D., Stahl, E. A., Duan, Q., Li, Y., Durda, P., Jiao, S., Isaacs, A., Hofman, A., Bis, J. C., Correa, A., Griswold, M. E., Jakobsdottir, J., Smith, A. V., Schreiner, P. J., Feitosa, M. F., Zhang, Q., Huffman, J. E., Crosby, J., Wassel, C. L., Do, R., Franceschini, N., Martin, L. W., Robinson, J. G. & NHLBI Grand Opportunity Exome Sequencing Project, 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 233-45 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2013

    Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., & 29 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkila, K., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M. & Author collaboration, Nov 2013, In: Nature Genetics. 45, 11, p. 1345-1352 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Common variants in Mendelian kidney disease genes and their association with renal function

    Parsa, A., Fuchsberger, C., Köttgen, A., O'Seaghdha, C. M., Pattaro, C., de Andrade, M., Chasman, D. I., Teumer, A., Endlich, K., Olden, M., Chen, M-H., Tin, A., Kim, Y. J., Taliun, D., Li, M., Feitosa, M., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., & 139 othersGlazer, N., Isaacs, A., Rao, M., Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Tönjes, A., Dehghan, A., Couraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, T. B., Launer, L. J., Aspelund, T., Eiriksdottir, G., Mitchell, B. D., Boerwinkle, E., Schmidt, H., Hofer, E., Hu, F., Demirkan, A., Oostra, B. A., Turner, S. T., Ding, J., Andrews, J. S., Freedman, B. I., Giulianini, F., Koenig, W., Illig, T., Döring, A., Wichmann, H-E., Zgaga, L., Zemunik, T., Boban, M., Minelli, C., Wheeler, H. E., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Ernst, F., Homuth, G., Kroemer, H. K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Aulchenko, Y. S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J. J., Stengel, B., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Colhoun, H., Doney, A., Robino, A., Krämer, B. K., Portas, L., Ford, I., Buckley, B. M., Adam, M., Thun, G-A., Paulweber, B., Haun, M., Sala, C., Mitchell, P., Ciullo, M., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J. W., Probst-Hensch, N. M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Ferrucci, L., van Duijn, C. M., Borecki, I., Kardia, S. L. R., Liu, Y., Curhan, G. C., Rudan, I., Gyllensten, U., Wilson, J. F., Franke, A., Pramstaller, P. P., Rettig, R., Prokopenko, I., Witteman, J., Hayward, C., Ridker, P. M., Bochud, M., Heid, I. M., Siscovick, D. S., Fox, C. S., Kao, W. L. & Böger, C. A., Dec 2013, In: Journal of the American Society of Nephrology. 24, 12, p. 2105-17 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Discovery and refinement of loci associated with lipid levels

    Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., & 31 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, Å., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Wong, A., Wolffenbuttel, B. H. R. & Global Lipids Genetics Consortium, Nov 2013, In: Nature Genetics. 45, 11, p. 1274-1283 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification

    Bos, D., Ikram, M. A., Isaacs, A., Verhaaren, B. F. J., Hofman, A., van Duijn, C. M., Witteman, J. C. M., van der Lugt, A. & Vernooij, M. W., Feb 2013, In: Circulation : Cardiovascular Genetics. 6, 1, p. 47-53 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

    Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., Gaffo, A. L., & 31 othersPirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., van der Harst, P., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J. L., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Isaacs, A., Wolffenbuttel, B. H. R. & LifeLines Cohort Study, Feb 2013, In: Nature Genetics. 45, 2, p. 145-54 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

    den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., & 32 othersBoucher, G., Cornelis, M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Wong, A., Global BPgen Consortium & Loos, R. J. F., Jun 2013, In: Nature Genetics. 45, 6, p. 621-31 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    CARDIOGRAM, METASTROKE, Keating, B. J. & Asselbergs, F. W., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1663-78 16 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

    Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., Henders, A., Nelson, C. P., Steves, C. J., Wright, M. J., de Craen, A. J. M., Isaacs, A., Matthews, M., Moayyeri, A., Montgomery, G. W., Oostra, B. A., & 7 othersVink, J. M., Spector, T. D., Slagboom, P. E., Martin, N. G., Samani, N. J., van Duijn, C. M. & Boomsma, D. I., Oct 2013, In: European Journal of Human Genetics. 21, 10, p. 1163-8 6 p.

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    Open Access

  • New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

    Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., Pfab, T., & 37 othersBarton, S. J., Shields, B. M., Kerkhof, M., van Leeuwen, E. M., Fulford, A. J., Kutalik, Z., Zhao, J. H., den Hoed, M., Mahajan, A., Lindi, V., Goh, L-K., Hottenga, J-J., Wu, Y., Raitakari, O. T., Harder, M. N., Meirhaeghe, A., Ntalla, I., Salem, R. M., Jameson, K. A., Zhou, K., Monies, D. M., Lagou, V., Kirin, M., Heikkinen, J., Adair, L. S., Alkuraya, F. S., Al-Odaib, A., Amouyel, P., Andersson, E. A., Isaacs, A., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), McCarthy, M. I., Jaddoe, V. W., Jarvelin, M-R., Timpson, N. J., Prokopenko, I. & Freathy, R., Jan 2013, In: Nature Genetics. 45, 1, p. 76-82 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

    Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A. & van Duijn, C. M., Mar 2013, In: Journal of Psychiatric Research. 47, 3, p. 357-62 6 p.

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  • Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia

    Brouwers, M. C. G. J., Konrad, R. J., van Himbergen, T. M., Isaacs, A., Otokozawa, S., Troutt, J. S., Schaefer, E. J., van Greevenbroek, M. M. J., Stalenhoef, A. F. H. & de Graaf, J., Nov 2013, In: Nutrition Metabolism and Cardiovascular Diseases. 23, 11, p. 1115-1121

    Research output: Contribution to journal › Article › Academic › peer-review

  • Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions

    Amin, N., Hottenga, J-J., Hansell, N. K., Janssens, A. C. J. W., de Moor, M. H. M., Madden, P. A. F., Zorkoltseva, I. V., Penninx, B. W., Terracciano, A., Uda, M., Tanaka, T., Esko, T., Realo, A., Ferrucci, L., Luciano, M., Davies, G., Metspalu, A., Abecasis, G. R., Deary, I. J., Raikkonen, K., & 19 othersBierut, L. J., Costa, P. T., Saviouk, V., Zhu, G., Kirichenko, A. V., Isaacs, A., Aulchenko, Y. S., Willemsen, G., Heath, A. C., Pergadia, M. L., Medland, S. E., Axenovich, T. I., de Geus, E., Montgomery, G. W., Wright, M. J., Oostra, B. A., Martin, N. G., Boomsma, D. I. & van Duijn, C. M., Aug 2013, In: European Journal of Human Genetics. 21, 8, p. 876-82 7 p.

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    Open Access

  • Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease

    Isaacs, A., Willems, S. M., Bos, D., Dehghan, A., Hofman, A., Ikram, M. A., Uitterlinden, A. G., Oostra, B. A., Franco, O. H., Witteman, J. C. & van Duijn, C. M., Sept 2013, In: Arteriosclerosis Thrombosis and Vascular Biology. 33, 9, p. 2233-9 7 p.

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    Open Access

  • The molecular genetic architecture of self-employment

    van der Loos, M. J. H. M., Rietveld, C. A., Eklund, N., Koellinger, P. D., Rivadeneira, F., Abecasis, G. R., Ankra-Badu, G. A., Baumeister, S. E., Benjamin, D. J., Biffar, R., Blankenberg, S., Boomsma, D. I., Cesarini, D., Cucca, F., de Geus, E. J. C., Dedoussis, G., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Eriksson, J., & 48 othersGieger, C., Gudnason, V., Höhne, B., Holle, R., Hottenga, J-J., Isaacs, A., Järvelin, M-R., Johannesson, M., Kaakinen, M., Kähönen, M., Kanoni, S., Laaksonen, M. A., Lahti, J., Launer, L. J., Lehtimäki, T., Loitfelder, M., Magnusson, P. K. E., Naitza, S., Oostra, B. A., Perola, M., Petrovic, K., Quaye, L., Raitakari, O., Ripatti, S., Scheet, P., Schlessinger, D., Schmidt, C. O., Schmidt, H., Schmidt, R., Senft, A., Smith, A. V., Spector, T. D., Surakka, I., Svento, R., Terracciano, A., Tikkanen, E., van Duijn, C. M., Viikari, J., Völzke, H., Wichmann, H-E., Wild, P. S., Willems, S. M., Willemsen, G., van Rooij, F. J. A., Groenen, P. J. F., Uitterlinden, A. G., Hofman, A. & Thurik, A. R., 2013, In: PLOS ONE. 8, 4, p. e60542

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    Open Access

  • The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

    Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A-P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V., & 31 othersKristiansson, K., Shen, H-Y., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M-L., Robertson, N., de Bruijn, R. F. A. G., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Döring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A-L., Heikkilä, K., Herzig, K-H., Holm, H., Hottenga, J. J., Hyppönen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J. & European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium, 2013, In: PLOS Medicine . 10, 6, p. e1001474

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    Open Access