Channel interference in mass cytometry can cause spillover and may result in miscounting of protein markers. We develop a nonparametric finite mixture model, and use the mixture components to estimate the probability of spillover. We implement our method using expectation-maximization to fit the mixture model.
Guazzini, M., Reisach, A., Weichwald, S. & Seiler, C., 27 Jan 2023.
Research output: Contribution to conference › Poster › Academic
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Guazzini, M. (Contributor), Reisach, A. (Contributor), Weichwald, S. (Creator), Seiler, C. (Contributor) (2023). spillR. Bioconductor. 10.18129/b9.bioc.spillr