White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability

Lotta-Katrin Pries; Sinan Guloksuz; Claudia Menne-Lothmann; Jeroen Decoster; Ruud van Winkel; Dina Collip; Philippe Delespaul; Marc De Hert; Catherine Derom; Evert Thiery; Nele Jacobs; Marieke Wichers; Claudia J. P. Simons; Bart P. F. Rutten; Jim van Os

doi:10.1371/journal.pone.0183695

White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability

Lotta-Katrin Pries, Sinan Guloksuz, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Claudia J. P. Simons, Bart P. F. Rutten, Jim van Os^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background

An association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting.

Objectives

The aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample. Findings were compared to previous results to investigate potential methodology dependent differences.

Methods

In a general population adolescent and young adult twin sample (n = 704), the association between white noise speech illusion and subclinical psychotic experiences, using the Structured Interview for Schizotypy-Revised (SIS-R) and the Community Assessment of Psychic Experiences (CAPE), was analyzed using multilevel logistic regression analyses.

Results

Perception of any white noise speech illusion was not associated with either positive or negative schizotypy in the general population twin sample, using the method by Galdos et al. (2011) (positive: ORadjusted: 0.82, 95% CI: 0.6-1.12, p = 0.217; negative: ORadjusted: 0.75, 95% CI: 0.56-1.02, p = 0.065) and the method by Catalan et al. (2014) (positive: ORadjusted: 1.11, 95% CI: 0.79-1.57, p = 0.557). No association was found between CAPE scores and speech illusion (ORadjusted: 1.25, 95% CI: 0.88-1.79, p = 0.220). For the Catalan et al. (2014) but not the Galdos et al. (2011) method, a negative association was apparent between positive schizotypy and speech illusion with positive or negative affective valence (ORadjusted: 0.44, 95% CI: 0.24-0.81, p = 0.008).

Conclusion

Contrary to findings in clinical populations, white noise speech illusion may not be associated with psychosis proneness in nonclinical populations.

Original language	English
Article number	0183695
Number of pages	10
Journal	PLOS ONE
Volume	12
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0183695
Publication status	Published - 23 Aug 2017

Keywords

AUDITORY-VERBAL HALLUCINATIONS
GENERAL-POPULATION
SCHIZOPHRENIA
ENVIRONMENT
RELIABILITY
PERCEPTION
DISORDER
HEARING

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Cite this

Pries, L.-K., Guloksuz, S., Menne-Lothmann, C., Decoster, J., van Winkel, R., Collip, D., Delespaul, P., De Hert, M., Derom, C., Thiery, E., Jacobs, N., Wichers, M., Simons, C. J. P., Rutten, B. P. F., & van Os, J. (2017). White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability. PLOS ONE, 12(8), Article 0183695. https://doi.org/10.1371/journal.pone.0183695

@article{59bf258f059648b28343afa353a20e19,

title = "White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability",

abstract = "BackgroundAn association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting.ObjectivesThe aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample. Findings were compared to previous results to investigate potential methodology dependent differences.MethodsIn a general population adolescent and young adult twin sample (n = 704), the association between white noise speech illusion and subclinical psychotic experiences, using the Structured Interview for Schizotypy-Revised (SIS-R) and the Community Assessment of Psychic Experiences (CAPE), was analyzed using multilevel logistic regression analyses.ResultsPerception of any white noise speech illusion was not associated with either positive or negative schizotypy in the general population twin sample, using the method by Galdos et al. (2011) (positive: ORadjusted: 0.82, 95% CI: 0.6-1.12, p = 0.217; negative: ORadjusted: 0.75, 95% CI: 0.56-1.02, p = 0.065) and the method by Catalan et al. (2014) (positive: ORadjusted: 1.11, 95% CI: 0.79-1.57, p = 0.557). No association was found between CAPE scores and speech illusion (ORadjusted: 1.25, 95% CI: 0.88-1.79, p = 0.220). For the Catalan et al. (2014) but not the Galdos et al. (2011) method, a negative association was apparent between positive schizotypy and speech illusion with positive or negative affective valence (ORadjusted: 0.44, 95% CI: 0.24-0.81, p = 0.008).ConclusionContrary to findings in clinical populations, white noise speech illusion may not be associated with psychosis proneness in nonclinical populations.",

keywords = "AUDITORY-VERBAL HALLUCINATIONS, GENERAL-POPULATION, SCHIZOPHRENIA, ENVIRONMENT, RELIABILITY, PERCEPTION, DISORDER, HEARING",

author = "Lotta-Katrin Pries and Sinan Guloksuz and Claudia Menne-Lothmann and Jeroen Decoster and {van Winkel}, Ruud and Dina Collip and Philippe Delespaul and {De Hert}, Marc and Catherine Derom and Evert Thiery and Nele Jacobs and Marieke Wichers and Simons, {Claudia J. P.} and Rutten, {Bart P. F.} and {van Os}, Jim",

year = "2017",

month = aug,

day = "23",

doi = "10.1371/journal.pone.0183695",

language = "English",

volume = "12",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

Pries, L-K, Guloksuz, S, Menne-Lothmann, C, Decoster, J, van Winkel, R, Collip, D, Delespaul, P, De Hert, M, Derom, C, Thiery, E, Jacobs, N, Wichers, M, Simons, CJP , Rutten, BPF & van Os, J 2017, 'White noise speech illusion and psychosis expression: An experimental investigation of psychosis liability', PLOS ONE, vol. 12, no. 8, 0183695. https://doi.org/10.1371/journal.pone.0183695

TY - JOUR

T1 - White noise speech illusion and psychosis expression

T2 - An experimental investigation of psychosis liability

AU - Pries, Lotta-Katrin

AU - Guloksuz, Sinan

AU - Menne-Lothmann, Claudia

AU - Decoster, Jeroen

AU - van Winkel, Ruud

AU - Collip, Dina

AU - Delespaul, Philippe

AU - De Hert, Marc

AU - Derom, Catherine

AU - Thiery, Evert

AU - Jacobs, Nele

AU - Wichers, Marieke

AU - Simons, Claudia J. P.

AU - Rutten, Bart P. F.

AU - van Os, Jim

PY - 2017/8/23

Y1 - 2017/8/23

N2 - BackgroundAn association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting.ObjectivesThe aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample. Findings were compared to previous results to investigate potential methodology dependent differences.MethodsIn a general population adolescent and young adult twin sample (n = 704), the association between white noise speech illusion and subclinical psychotic experiences, using the Structured Interview for Schizotypy-Revised (SIS-R) and the Community Assessment of Psychic Experiences (CAPE), was analyzed using multilevel logistic regression analyses.ResultsPerception of any white noise speech illusion was not associated with either positive or negative schizotypy in the general population twin sample, using the method by Galdos et al. (2011) (positive: ORadjusted: 0.82, 95% CI: 0.6-1.12, p = 0.217; negative: ORadjusted: 0.75, 95% CI: 0.56-1.02, p = 0.065) and the method by Catalan et al. (2014) (positive: ORadjusted: 1.11, 95% CI: 0.79-1.57, p = 0.557). No association was found between CAPE scores and speech illusion (ORadjusted: 1.25, 95% CI: 0.88-1.79, p = 0.220). For the Catalan et al. (2014) but not the Galdos et al. (2011) method, a negative association was apparent between positive schizotypy and speech illusion with positive or negative affective valence (ORadjusted: 0.44, 95% CI: 0.24-0.81, p = 0.008).ConclusionContrary to findings in clinical populations, white noise speech illusion may not be associated with psychosis proneness in nonclinical populations.

AB - BackgroundAn association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting.ObjectivesThe aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample. Findings were compared to previous results to investigate potential methodology dependent differences.MethodsIn a general population adolescent and young adult twin sample (n = 704), the association between white noise speech illusion and subclinical psychotic experiences, using the Structured Interview for Schizotypy-Revised (SIS-R) and the Community Assessment of Psychic Experiences (CAPE), was analyzed using multilevel logistic regression analyses.ResultsPerception of any white noise speech illusion was not associated with either positive or negative schizotypy in the general population twin sample, using the method by Galdos et al. (2011) (positive: ORadjusted: 0.82, 95% CI: 0.6-1.12, p = 0.217; negative: ORadjusted: 0.75, 95% CI: 0.56-1.02, p = 0.065) and the method by Catalan et al. (2014) (positive: ORadjusted: 1.11, 95% CI: 0.79-1.57, p = 0.557). No association was found between CAPE scores and speech illusion (ORadjusted: 1.25, 95% CI: 0.88-1.79, p = 0.220). For the Catalan et al. (2014) but not the Galdos et al. (2011) method, a negative association was apparent between positive schizotypy and speech illusion with positive or negative affective valence (ORadjusted: 0.44, 95% CI: 0.24-0.81, p = 0.008).ConclusionContrary to findings in clinical populations, white noise speech illusion may not be associated with psychosis proneness in nonclinical populations.

KW - AUDITORY-VERBAL HALLUCINATIONS

KW - GENERAL-POPULATION

KW - SCHIZOPHRENIA

KW - ENVIRONMENT

KW - RELIABILITY

KW - PERCEPTION

KW - DISORDER

KW - HEARING

U2 - 10.1371/journal.pone.0183695

DO - 10.1371/journal.pone.0183695

M3 - Article

C2 - 28832672

SN - 1932-6203

VL - 12

JO - PLOS ONE

JF - PLOS ONE

IS - 8

M1 - 0183695

ER -