Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways

Amnah Siddiqa, Elisa Cirillo, Samar H K Tareen, Amjad Ali, Martina Kutmon, Lars Eijssen, Jamil Ahmad*, Chris T Evelo, Susan L Coort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature. With increasing number of studies targeting the regulation of ANGPTL8, integration of their findings becomes indispensable. This study has been conducted with the aim to collect, analyze, integrate and visualize the available knowledge in the literature about ANGPTL8 and its regulation. We utilized this knowledge to construct a regulatory pathway of ANGPTL8 which is available at WikiPathways, an open source pathways database. It allows us to visualize ANGPTL8's regulation with respect to other genes/proteins in different pathways helping us to understand the complex interplay of novel hormones/genes/proteins in metabolic disorders. To the best of our knowledge, this is the first attempt to present an integrated pathway view of ANGPTL8's regulation and its associated pathways and is important resource for future omics-based studies.

Original languageEnglish
Pages (from-to)408-418
Number of pages11
JournalGenomics
Volume109
Issue number5-6
Early online date4 Jul 2017
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Journal Article
  • FOXO
  • THYROID-HORMONE
  • BETATROPHIN
  • LPL
  • Betatrophin
  • Lipid/glucose metabolism
  • INSULIN
  • ANGPTL8 regulatory pathway
  • GENE
  • KINASE B
  • ANGPTL8
  • ANIMAL-MODELS
  • MICE
  • BETA-CELL PROLIFERATION
  • EXPRESSION

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