Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants

Francesco M. Risso; Laura D. Serpero; Luc J. I. Zimmermann; Antonio W. D. Gavilanes; Rosanna Frulio; Fabrizio Michetti; Pasquale Florio; Moataza Bashir; Iman Iskander; Hala Mufeed; Hanna Aboulgar; Diego Gazzolo

doi:10.1111/apa.12343

Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants

Francesco M. Risso, Laura D. Serpero, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Rosanna Frulio, Fabrizio Michetti, Pasquale Florio, Moataza Bashir, Iman Iskander, Hala Mufeed, Hanna Aboulgar, Diego Gazzolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA). Methods The study compared 38 full-term newborns with PA [neonatal death n=11; hypoxic ischaemic encephalopathy (HIE): n=27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recordedat eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death. Results A1B and BB in PA nonsurvivor infants were significantly higher (p42ng/L) was the best predictor of early neonatal death (p

Original language	English
Pages (from-to)	E467-E472
Journal	Acta Paediatrica
Volume	102
Issue number	10
DOIs	https://doi.org/10.1111/apa.12343
Publication status	Published - Oct 2013

Keywords

Asphyxia
Hypoxic ischaemic encephalopathy
Neonatal death
S100A1B
S100BB

Access to Document

10.1111/apa.12343

Cite this

@article{2f2191ecd13b4682aacee8f0a46fbfa8,

title = "Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants",

abstract = "Aim To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA). Methods The study compared 38 full-term newborns with PA [neonatal death n=11; hypoxic ischaemic encephalopathy (HIE): n=27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recordedat eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death. Results A1B and BB in PA nonsurvivor infants were significantly higher (p42ng/L) was the best predictor of early neonatal death (p",

keywords = "Asphyxia, Hypoxic ischaemic encephalopathy, Neonatal death, S100A1B, S100BB",

author = "Risso, {Francesco M.} and Serpero, {Laura D.} and Zimmermann, {Luc J. I.} and Gavilanes, {Antonio W. D.} and Rosanna Frulio and Fabrizio Michetti and Pasquale Florio and Moataza Bashir and Iman Iskander and Hala Mufeed and Hanna Aboulgar and Diego Gazzolo",

year = "2013",

month = oct,

doi = "10.1111/apa.12343",

language = "English",

volume = "102",

pages = "E467--E472",

journal = "Acta Paediatrica",

issn = "0803-5253",

publisher = "Wiley",

number = "10",

}

TY - JOUR

T1 - Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants

AU - Risso, Francesco M.

AU - Serpero, Laura D.

AU - Zimmermann, Luc J. I.

AU - Gavilanes, Antonio W. D.

AU - Frulio, Rosanna

AU - Michetti, Fabrizio

AU - Florio, Pasquale

AU - Bashir, Moataza

AU - Iskander, Iman

AU - Mufeed, Hala

AU - Aboulgar, Hanna

AU - Gazzolo, Diego

PY - 2013/10

Y1 - 2013/10

N2 - Aim To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA). Methods The study compared 38 full-term newborns with PA [neonatal death n=11; hypoxic ischaemic encephalopathy (HIE): n=27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recordedat eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death. Results A1B and BB in PA nonsurvivor infants were significantly higher (p42ng/L) was the best predictor of early neonatal death (p

AB - Aim To investigate whether S100A1B and BB dimers are predictors of early perinatal death in newborns with perinatal asphyxia (PA). Methods The study compared 38 full-term newborns with PA [neonatal death n=11; hypoxic ischaemic encephalopathy (HIE): n=27] with a control group of 38 healthy infants. Clinical and laboratory parameters were recordedat eight time points and urine collected for S100B assessment. Multivariate analysis was performed in order to analyse the influence of various clinical parameters on the occurrence of neonatal death. Results A1B and BB in PA nonsurvivor infants were significantly higher (p42ng/L) was the best predictor of early neonatal death (p

KW - Asphyxia

KW - Hypoxic ischaemic encephalopathy

KW - Neonatal death

KW - S100A1B

KW - S100BB

U2 - 10.1111/apa.12343

DO - 10.1111/apa.12343

M3 - Article

C2 - 23826805

SN - 0803-5253

VL - 102

SP - E467-E472

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 10

ER -