Ureaplasma and BPD

Suhas G. Kallapur; Boris W. Kramer; Alan H. Jobe

doi:10.1053/j.semperi.2013.01.005

Ureaplasma and BPD

Suhas G. Kallapur^*, Boris W. Kramer, Alan H. Jobe

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ureaplasma is an organism with low virulence and is a commensal of the lower genito-urinary tract in females. From here, it can gain entry in the amniotic fluid to cause inflammation in the amniotic compartment during pregnancy. Ureaplasma spp. are the most common organisms isolated from women with chorioamnionitis. Ureaplasma spp. are associated with increased risk for preterm labor and morbidity in the preterm neonate. However, there is some controversy regarding the importance of Ureaplasma in the pathogenesis of bronchopulmonary dysplasia (BPD). This article will review the microbiology of Ureaplasma, host innate immune responses, and the pathology of lung injury in animal models of Ureaplasma chorioamnionitis. We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD.

Original language	English
Pages (from-to)	94-101
Journal	Seminars in Perinatology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1053/j.semperi.2013.01.005
Publication status	Published - Apr 2013

Keywords

Chorioamnionitis
Prematurity
Fetal Inflammation
Lung injury

Access to Document

10.1053/j.semperi.2013.01.005

Cite this

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title = "Ureaplasma and BPD",

abstract = "Ureaplasma is an organism with low virulence and is a commensal of the lower genito-urinary tract in females. From here, it can gain entry in the amniotic fluid to cause inflammation in the amniotic compartment during pregnancy. Ureaplasma spp. are the most common organisms isolated from women with chorioamnionitis. Ureaplasma spp. are associated with increased risk for preterm labor and morbidity in the preterm neonate. However, there is some controversy regarding the importance of Ureaplasma in the pathogenesis of bronchopulmonary dysplasia (BPD). This article will review the microbiology of Ureaplasma, host innate immune responses, and the pathology of lung injury in animal models of Ureaplasma chorioamnionitis. We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD. ",

keywords = "Chorioamnionitis, Prematurity, Fetal Inflammation, Lung injury",

author = "Kallapur, {Suhas G.} and Kramer, {Boris W.} and Jobe, {Alan H.}",

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TY - JOUR

T1 - Ureaplasma and BPD

AU - Kallapur, Suhas G.

AU - Kramer, Boris W.

AU - Jobe, Alan H.

PY - 2013/4

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N2 - Ureaplasma is an organism with low virulence and is a commensal of the lower genito-urinary tract in females. From here, it can gain entry in the amniotic fluid to cause inflammation in the amniotic compartment during pregnancy. Ureaplasma spp. are the most common organisms isolated from women with chorioamnionitis. Ureaplasma spp. are associated with increased risk for preterm labor and morbidity in the preterm neonate. However, there is some controversy regarding the importance of Ureaplasma in the pathogenesis of bronchopulmonary dysplasia (BPD). This article will review the microbiology of Ureaplasma, host innate immune responses, and the pathology of lung injury in animal models of Ureaplasma chorioamnionitis. We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD.

AB - Ureaplasma is an organism with low virulence and is a commensal of the lower genito-urinary tract in females. From here, it can gain entry in the amniotic fluid to cause inflammation in the amniotic compartment during pregnancy. Ureaplasma spp. are the most common organisms isolated from women with chorioamnionitis. Ureaplasma spp. are associated with increased risk for preterm labor and morbidity in the preterm neonate. However, there is some controversy regarding the importance of Ureaplasma in the pathogenesis of bronchopulmonary dysplasia (BPD). This article will review the microbiology of Ureaplasma, host innate immune responses, and the pathology of lung injury in animal models of Ureaplasma chorioamnionitis. We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD.

KW - Chorioamnionitis

KW - Prematurity

KW - Fetal Inflammation

KW - Lung injury

U2 - 10.1053/j.semperi.2013.01.005

DO - 10.1053/j.semperi.2013.01.005

M3 - Article

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SN - 0146-0005

VL - 37

SP - 94

EP - 101

JO - Seminars in Perinatology

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