TY - JOUR
T1 - Unstable coronary plaque characteristics are associated with high sensitivity cardiac troponin T and N-terminal Pro-Brain Natriuretic Peptide
AU - Altintas, Sibel
AU - Cardinaels, Eline
AU - Versteylen, Mathijs O.
AU - Joosen, Ivo A.
AU - Seifert, H.
AU - Wildberger, Joachim E.
AU - Crijns, Harry J.
AU - Nelemans, Patricia J.
AU - van Dieijen - Visser, Marja P.
AU - Mingels, Alma M. A.
AU - Das, Marco
AU - Kietselaer, Bas L.
PY - 2016
Y1 - 2016
N2 - Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values
AB - Background: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. Objective: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. Methods: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. Results: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values
KW - Coronary CT angiography
KW - Coronary plaque
KW - Plaque volume
KW - Plaque burden
KW - Plaque quantification
KW - Quantitative coronary tree analysis
KW - Biological markers
KW - Cardiac troponin
KW - Natriuretic peptide
U2 - 10.1016/j.jcct.2015.10.001
DO - 10.1016/j.jcct.2015.10.001
M3 - Article
C2 - 26481512
SN - 1934-5925
VL - 10
SP - 82
EP - 88
JO - Journal of Cardiovascular Computed Tomography
JF - Journal of Cardiovascular Computed Tomography
IS - 1
ER -