Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration

D.G.H.A. van Dam; D. M. T. Burgers; N. Foudraine; P. K. C. Janssen; C. Neef; J. L. M. L. le Noble

Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration

D.G.H.A. van Dam^*, D. M. T. Burgers, N. Foudraine, P. K. C. Janssen, C. Neef, J. L. M. L. le Noble

^*Corresponding author for this work

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Abstract

A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.

Original language	English
Pages (from-to)	32-34
Journal	Netherlands Journal of Medicine
Volume	75
Issue number	1
Publication status	Published - Jan 2017

Keywords

Cefuroxime
haemofiltration
intoxication
neurotoxicity
toxicokinetics

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Full TextFinal published version, 208 KBLicence: Taverne

http://www.njmonline.nl/getpdf.php?id=1801

Cite this

@article{32572e13c9ac4c46b5b78fb0e2508d9f,

title = "Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration",

abstract = "A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.",

keywords = "Cefuroxime, haemofiltration, intoxication, neurotoxicity, toxicokinetics",

author = "{van Dam}, D.G.H.A. and Burgers, {D. M. T.} and N. Foudraine and Janssen, {P. K. C.} and C. Neef and {le Noble}, {J. L. M. L.}",

year = "2017",

month = jan,

language = "English",

volume = "75",

pages = "32--34",

journal = "Netherlands Journal of Medicine",

issn = "0300-2977",

publisher = "Van Zuiden Communications",

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}

TY - JOUR

T1 - Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration

AU - van Dam, D.G.H.A.

AU - Burgers, D. M. T.

AU - Foudraine, N.

AU - Janssen, P. K. C.

AU - Neef, C.

AU - le Noble, J. L. M. L.

PY - 2017/1

Y1 - 2017/1

N2 - A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.

AB - A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.

KW - Cefuroxime

KW - haemofiltration

KW - intoxication

KW - neurotoxicity

KW - toxicokinetics

M3 - Article

SN - 0300-2977

VL - 75

SP - 32

EP - 34

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 1

ER -