Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

S. Schipper; M. W. Aalbers; K. Rijkers; A. Swijsen; J. M. Rigo; G. Hoogland; J. S. H. Vles

doi:10.1007/s12035-015-9423-8

Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

S. Schipper^*, M. W. Aalbers, K. Rijkers, A. Swijsen, J. M. Rigo, G. Hoogland, J. S. H. Vles

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.

Original language	English
Pages (from-to)	5252-5265
Journal	Molecular Neurobiology
Volume	53
Issue number	8
DOIs	https://doi.org/10.1007/s12035-015-9423-8
Publication status	Published - Oct 2016

Keywords

Extrasynaptic GABA(A) receptor
Epilepsy
Seizures
Tonic
Antiepileptic drugs

Access to Document

10.1007/s12035-015-9423-8Licence: CC BY

Cite this

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title = "Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy",

abstract = "Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.",

keywords = "Extrasynaptic GABA(A) receptor, Epilepsy, Seizures, Tonic, Antiepileptic drugs",

author = "S. Schipper and Aalbers, {M. W.} and K. Rijkers and A. Swijsen and Rigo, {J. M.} and G. Hoogland and Vles, {J. S. H.}",

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AU - Schipper, S.

AU - Aalbers, M. W.

AU - Rijkers, K.

AU - Swijsen, A.

AU - Rigo, J. M.

AU - Hoogland, G.

AU - Vles, J. S. H.

PY - 2016/10

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N2 - Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.

AB - Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.

KW - Extrasynaptic GABA(A) receptor

KW - Epilepsy

KW - Seizures

KW - Tonic

KW - Antiepileptic drugs

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DO - 10.1007/s12035-015-9423-8

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EP - 5265

JO - Molecular Neurobiology

JF - Molecular Neurobiology

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