Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium

M.B. Cook; P. Guénel; S.M. Gapstur; P.A. van den Brandt; K.B. Michels; J.T. Casagrande; R. Cooke; S.K. van den Eeden; M. Ewertz; R.T. Falk; M.M. Gaudet; G. Gkiokas; L.A. Habel; A.W. Hsing; K. Johnson; L.N. Kolonel; C. la Vecchia; E. Lynge; J.H. Lubin; V.A. McCormack; E. Negri; H. Olsson; D. Parisi; E.T. Petridou; E. Riboli; H.D. Sesso; A. Swerdlow; D.B. Thomas; W.C. Willett; L.A. Brinton

doi:10.1158/1055-9965.EPI-14-1009

Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium

M.B. Cook^*, P. Guénel, S.M. Gapstur, P.A. van den Brandt, K.B. Michels, J.T. Casagrande, R. Cooke, S.K. van den Eeden, M. Ewertz, R.T. Falk, M.M. Gaudet, G. Gkiokas, L.A. Habel, A.W. Hsing, K. Johnson, L.N. Kolonel, C. la Vecchia, E. Lynge, J.H. Lubin, V.A. McCormackE. Negri, H. Olsson, D. Parisi, E.T. Petridou, E. Riboli, H.D. Sesso, A. Swerdlow, D.B. Thomas, W.C. Willett, L.A. Brinton

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.

Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.

Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (> 60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-

Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.

Original language	English
Pages (from-to)	520-531
Number of pages	12
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	24
Issue number	3
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-1009
Publication status	Published - Mar 2015

Keywords

BASE-LINE CHARACTERISTICS
MODELING TOTAL EXPOSURE
BODY-MASS INDEX
RISK-FACTORS
CIGARETTE-SMOKING
UNITED-STATES
MENSTRUAL-CYCLE
ACTIVE SMOKING
FOLLOW-UP
MEN

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10.1158/1055-9965.EPI-14-1009

Cite this

Cook, M. B., Guénel, P., Gapstur, S. M., van den Brandt, P. A., Michels, K. B., Casagrande, J. T., Cooke, R., van den Eeden, S. K., Ewertz, M., Falk, R. T., Gaudet, M. M., Gkiokas, G., Habel, L. A., Hsing, A. W., Johnson, K., Kolonel, L. N., la Vecchia, C., Lynge, E., Lubin, J. H., ... Brinton, L. A. (2015). Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium. Cancer Epidemiology Biomarkers & Prevention, 24(3), 520-531. https://doi.org/10.1158/1055-9965.EPI-14-1009

@article{10bec882c26a4a7f8e98fa4893fd9bc5,

title = "Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium",

abstract = "Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (> 60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer. (c) 2014 AACR.",

keywords = "BASE-LINE CHARACTERISTICS, MODELING TOTAL EXPOSURE, BODY-MASS INDEX, RISK-FACTORS, CIGARETTE-SMOKING, UNITED-STATES, MENSTRUAL-CYCLE, ACTIVE SMOKING, FOLLOW-UP, MEN",

author = "M.B. Cook and P. Gu{\'e}nel and S.M. Gapstur and {van den Brandt}, P.A. and K.B. Michels and J.T. Casagrande and R. Cooke and {van den Eeden}, S.K. and M. Ewertz and R.T. Falk and M.M. Gaudet and G. Gkiokas and L.A. Habel and A.W. Hsing and K. Johnson and L.N. Kolonel and {la Vecchia}, C. and E. Lynge and J.H. Lubin and V.A. McCormack and E. Negri and H. Olsson and D. Parisi and E.T. Petridou and E. Riboli and H.D. Sesso and A. Swerdlow and D.B. Thomas and W.C. Willett and L.A. Brinton",

year = "2015",

month = mar,

doi = "10.1158/1055-9965.EPI-14-1009",

language = "English",

volume = "24",

pages = "520--531",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "3",

}

Cook, MB, Guénel, P, Gapstur, SM, van den Brandt, PA, Michels, KB, Casagrande, JT, Cooke, R, van den Eeden, SK, Ewertz, M, Falk, RT, Gaudet, MM, Gkiokas, G, Habel, LA, Hsing, AW, Johnson, K, Kolonel, LN, la Vecchia, C, Lynge, E, Lubin, JH, McCormack, VA, Negri, E, Olsson, H, Parisi, D, Petridou, ET, Riboli, E, Sesso, HD, Swerdlow, A, Thomas, DB, Willett, WC & Brinton, LA 2015, 'Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium', Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 3, pp. 520-531. https://doi.org/10.1158/1055-9965.EPI-14-1009

TY - JOUR

T1 - Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium

AU - Cook, M.B.

AU - Guénel, P.

AU - Gapstur, S.M.

AU - van den Brandt, P.A.

AU - Michels, K.B.

AU - Casagrande, J.T.

AU - Cooke, R.

AU - van den Eeden, S.K.

AU - Ewertz, M.

AU - Falk, R.T.

AU - Gaudet, M.M.

AU - Gkiokas, G.

AU - Habel, L.A.

AU - Hsing, A.W.

AU - Johnson, K.

AU - Kolonel, L.N.

AU - la Vecchia, C.

AU - Lynge, E.

AU - Lubin, J.H.

AU - McCormack, V.A.

AU - Negri, E.

AU - Olsson, H.

AU - Parisi, D.

AU - Petridou, E.T.

AU - Riboli, E.

AU - Sesso, H.D.

AU - Swerdlow, A.

AU - Thomas, D.B.

AU - Willett, W.C.

AU - Brinton, L.A.

PY - 2015/3

Y1 - 2015/3

N2 - Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (> 60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer. (c) 2014 AACR.

AB - Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (> 60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer. (c) 2014 AACR.

KW - BASE-LINE CHARACTERISTICS

KW - MODELING TOTAL EXPOSURE

KW - BODY-MASS INDEX

KW - RISK-FACTORS

KW - CIGARETTE-SMOKING

KW - UNITED-STATES

KW - MENSTRUAL-CYCLE

KW - ACTIVE SMOKING

KW - FOLLOW-UP

KW - MEN

U2 - 10.1158/1055-9965.EPI-14-1009

DO - 10.1158/1055-9965.EPI-14-1009

M3 - Article

C2 - 25515550

SN - 1055-9965

VL - 24

SP - 520

EP - 531

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 3

ER -