Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe

Y. H. M. Claassen; E. Bastiaannet; E. van Eycken; N. Van Damme; A. Martling; R. Johansson; L. H. Iversen; P. Ingeholm; V. E. P. P. Lemmens; G. J. Liefers; F. A. Holman; J. W. T. Dekker; J. E. A. Portielje; H. J. Rutten; C. J. H. van de Velde

doi:10.1016/j.ejso.2019.03.041

Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe

Y. H. M. Claassen^*, E. Bastiaannet, E. van Eycken, N. Van Damme, A. Martling, R. Johansson, L. H. Iversen, P. Ingeholm, V. E. P. P. Lemmens, G. J. Liefers, F. A. Holman, J. W. T. Dekker, J. E. A. Portielje, H. J. Rutten, C. J. H. van de Velde

^*Corresponding author for this work

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Abstract

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (>= 80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-Ill) between 2005 and 2014, were included. Population-based cohorts from Belgium, Denmark, the Netherlands, and Sweden were collected. Separately for colon- and rectal cancer, 30-day, 90-day, one-year, and excess one-year mortality were calculated. Also, short-term mortality over three time periods (2005-2008, 2009-2011, 2012-2014) was analyzed.

Results: In total, 35,158 colon cancer patients and 10,144 rectal cancer patients were included. For colon cancer, 90-day mortality rate was highest in Denmark (15%) and lowest in Sweden (8%). For rectal cancer, 90-day mortality rate was highest in Belgium (11%) and lowest in Sweden (7%). One-year excess mortality rate of colon cancer patients decreased from 2005 to 2008 to 2012-2014 for all countries (Belgium: 17%-11%, Denmark: 21%-15%, the Netherlands: 18%-10%, and Sweden: 10%-8%). For rectal cancer, from 2005 to 2008 to 2012-2014 one-year excess mortality rate decreased in the Netherlands from 16% to 7% and Sweden: 8%-2%).

Conclusions: Short-term mortality rates were high in octogenarians operated for colorectal cancer. Short-term mortality rates differ across four North European countries, but decreased over time for both colon and rectal cancer patients in all countries. (C) 2019 Published by Elsevier Ltd.

Original language	English
Pages (from-to)	1396-1402
Number of pages	7
Journal	European Journal of Surgical Oncology
Volume	45
Issue number	8
DOIs	https://doi.org/10.1016/j.ejso.2019.03.041
Publication status	Published - Aug 2019

Keywords

Colorectal cancer
Short-term mortality
Elderly
Octogenarians
ENHANCED-RECOVERY
30-DAY MORTALITY
CANCER-PATIENTS
COLON-CANCER
SURGERY
COMPLICATIONS
SURVIVAL
COUNTRIES
CARE

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Claassen, Y. H. M., Bastiaannet, E., van Eycken, E., Van Damme, N., Martling, A., Johansson, R., Iversen, L. H., Ingeholm, P., Lemmens, V. E. P. P., Liefers, G. J., Holman, F. A., Dekker, J. W. T., Portielje, J. E. A., Rutten, H. J., & van de Velde, C. J. H. (2019). Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe. European Journal of Surgical Oncology, 45(8), 1396-1402. https://doi.org/10.1016/j.ejso.2019.03.041

@article{85c3530dda7d47f8b5ccc69d2cbdda91,

title = "Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe",

abstract = "Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (>= 80 years) with colorectal cancer across four North European countries.Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-Ill) between 2005 and 2014, were included. Population-based cohorts from Belgium, Denmark, the Netherlands, and Sweden were collected. Separately for colon- and rectal cancer, 30-day, 90-day, one-year, and excess one-year mortality were calculated. Also, short-term mortality over three time periods (2005-2008, 2009-2011, 2012-2014) was analyzed.Results: In total, 35,158 colon cancer patients and 10,144 rectal cancer patients were included. For colon cancer, 90-day mortality rate was highest in Denmark (15%) and lowest in Sweden (8%). For rectal cancer, 90-day mortality rate was highest in Belgium (11%) and lowest in Sweden (7%). One-year excess mortality rate of colon cancer patients decreased from 2005 to 2008 to 2012-2014 for all countries (Belgium: 17%-11%, Denmark: 21%-15%, the Netherlands: 18%-10%, and Sweden: 10%-8%). For rectal cancer, from 2005 to 2008 to 2012-2014 one-year excess mortality rate decreased in the Netherlands from 16% to 7% and Sweden: 8%-2%).Conclusions: Short-term mortality rates were high in octogenarians operated for colorectal cancer. Short-term mortality rates differ across four North European countries, but decreased over time for both colon and rectal cancer patients in all countries. (C) 2019 Published by Elsevier Ltd.",

keywords = "Colorectal cancer, Short-term mortality, Elderly, Octogenarians, ENHANCED-RECOVERY, 30-DAY MORTALITY, CANCER-PATIENTS, COLON-CANCER, SURGERY, COMPLICATIONS, SURVIVAL, COUNTRIES, CARE",

author = "Claassen, {Y. H. M.} and E. Bastiaannet and {van Eycken}, E. and {Van Damme}, N. and A. Martling and R. Johansson and Iversen, {L. H.} and P. Ingeholm and Lemmens, {V. E. P. P.} and Liefers, {G. J.} and Holman, {F. A.} and Dekker, {J. W. T.} and Portielje, {J. E. A.} and Rutten, {H. J.} and {van de Velde}, {C. J. H.}",

note = "Funding Information: The study was initiated by EUropean REgistration of Cancer CAre (EURECCA) which is funded by the European Society of Surgical Oncology (ESSO) . ESSO did not have a role in the study design, data collection, analysis, interpretation of the data, writing of the manuscript, or the decision to publish. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = aug,

doi = "10.1016/j.ejso.2019.03.041",

language = "English",

volume = "45",

pages = "1396--1402",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

publisher = "ELSEVIER SCI LTD",

number = "8",

}

Claassen, YHM, Bastiaannet, E, van Eycken, E, Van Damme, N, Martling, A, Johansson, R, Iversen, LH, Ingeholm, P, Lemmens, VEPP, Liefers, GJ, Holman, FA, Dekker, JWT, Portielje, JEA, Rutten, HJ & van de Velde, CJH 2019, 'Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe', European Journal of Surgical Oncology, vol. 45, no. 8, pp. 1396-1402. https://doi.org/10.1016/j.ejso.2019.03.041

TY - JOUR

T1 - Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe

AU - Claassen, Y. H. M.

AU - Bastiaannet, E.

AU - van Eycken, E.

AU - Van Damme, N.

AU - Martling, A.

AU - Johansson, R.

AU - Iversen, L. H.

AU - Ingeholm, P.

AU - Lemmens, V. E. P. P.

AU - Liefers, G. J.

AU - Holman, F. A.

AU - Dekker, J. W. T.

AU - Portielje, J. E. A.

AU - Rutten, H. J.

AU - van de Velde, C. J. H.

N1 - Funding Information: The study was initiated by EUropean REgistration of Cancer CAre (EURECCA) which is funded by the European Society of Surgical Oncology (ESSO) . ESSO did not have a role in the study design, data collection, analysis, interpretation of the data, writing of the manuscript, or the decision to publish. Publisher Copyright: © 2019

PY - 2019/8

Y1 - 2019/8

N2 - Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (>= 80 years) with colorectal cancer across four North European countries.Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-Ill) between 2005 and 2014, were included. Population-based cohorts from Belgium, Denmark, the Netherlands, and Sweden were collected. Separately for colon- and rectal cancer, 30-day, 90-day, one-year, and excess one-year mortality were calculated. Also, short-term mortality over three time periods (2005-2008, 2009-2011, 2012-2014) was analyzed.Results: In total, 35,158 colon cancer patients and 10,144 rectal cancer patients were included. For colon cancer, 90-day mortality rate was highest in Denmark (15%) and lowest in Sweden (8%). For rectal cancer, 90-day mortality rate was highest in Belgium (11%) and lowest in Sweden (7%). One-year excess mortality rate of colon cancer patients decreased from 2005 to 2008 to 2012-2014 for all countries (Belgium: 17%-11%, Denmark: 21%-15%, the Netherlands: 18%-10%, and Sweden: 10%-8%). For rectal cancer, from 2005 to 2008 to 2012-2014 one-year excess mortality rate decreased in the Netherlands from 16% to 7% and Sweden: 8%-2%).Conclusions: Short-term mortality rates were high in octogenarians operated for colorectal cancer. Short-term mortality rates differ across four North European countries, but decreased over time for both colon and rectal cancer patients in all countries. (C) 2019 Published by Elsevier Ltd.

AB - Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (>= 80 years) with colorectal cancer across four North European countries.Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-Ill) between 2005 and 2014, were included. Population-based cohorts from Belgium, Denmark, the Netherlands, and Sweden were collected. Separately for colon- and rectal cancer, 30-day, 90-day, one-year, and excess one-year mortality were calculated. Also, short-term mortality over three time periods (2005-2008, 2009-2011, 2012-2014) was analyzed.Results: In total, 35,158 colon cancer patients and 10,144 rectal cancer patients were included. For colon cancer, 90-day mortality rate was highest in Denmark (15%) and lowest in Sweden (8%). For rectal cancer, 90-day mortality rate was highest in Belgium (11%) and lowest in Sweden (7%). One-year excess mortality rate of colon cancer patients decreased from 2005 to 2008 to 2012-2014 for all countries (Belgium: 17%-11%, Denmark: 21%-15%, the Netherlands: 18%-10%, and Sweden: 10%-8%). For rectal cancer, from 2005 to 2008 to 2012-2014 one-year excess mortality rate decreased in the Netherlands from 16% to 7% and Sweden: 8%-2%).Conclusions: Short-term mortality rates were high in octogenarians operated for colorectal cancer. Short-term mortality rates differ across four North European countries, but decreased over time for both colon and rectal cancer patients in all countries. (C) 2019 Published by Elsevier Ltd.

KW - Colorectal cancer

KW - Short-term mortality

KW - Elderly

KW - Octogenarians

KW - ENHANCED-RECOVERY

KW - 30-DAY MORTALITY

KW - CANCER-PATIENTS

KW - COLON-CANCER

KW - SURGERY

KW - COMPLICATIONS

KW - SURVIVAL

KW - COUNTRIES

KW - CARE

U2 - 10.1016/j.ejso.2019.03.041

DO - 10.1016/j.ejso.2019.03.041

M3 - Article

C2 - 31003722

SN - 0748-7983

VL - 45

SP - 1396

EP - 1402

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 8

ER -