TY - JOUR
T1 - Three-Year Nationwide Experience with Transanal Total Mesorectal Excision for Rectal Cancer in the Netherlands
T2 - A Propensity Score-Matched Comparison with Conventional Laparoscopic Total Mesorectal Excision
AU - Detering, Robin
AU - Roodbeen, Sapho X.
AU - van Oostendorp, Stefan E.
AU - Dekker, Jan-Willem T.
AU - Sietses, Colin
AU - Bemelman, Willem A.
AU - Tanis, Pieter J.
AU - Hompes, Roel
AU - Tuynman, Jurriaan B.
AU - Aalbers, A. G. J.
AU - van Leeuwenhoek, Antoni
AU - Beets-Tan, R. G. H.
AU - den Boer, F. C.
AU - Breukink, S. O.
AU - Coene, P. P. L. O.
AU - Doornebosch, P. G.
AU - Gelderblom, A. J.
AU - Karsten, T. M.
AU - Ledeboer, M.
AU - Manusama, E. R.
AU - Marijnen, C. A. M.
AU - Nagtegaal, I. D.
AU - Peeters, K. C. M. J.
AU - Tollenaar, R. A. E. M.
AU - de Velde, C. J. H. van
AU - Wagner, A.
AU - Westerterp, M.
AU - van Westreenen, H. L.
AU - Dutch ColoRectal Cancer Audit Group
N1 - Publisher Copyright:
© 2019 American College of Surgeons
PY - 2019/3
Y1 - 2019/3
N2 - BACKGROUND: Transanal total mesorectal excision (TaTME) is a relatively new and demanding technique for rectal cancer treatment. Results from national datasets are absent and comparative data with laparoscopic TME (lapTME) are scarce. Therefore, this study aimed to evaluate the initial TaTME experience in the Netherlands, by comparing outcomes with conventional lapTME.STUDY DESIGN: Patients with rectal cancer who underwent curative TaTME or lapTME were selected from the nationwide and mandatory Dutch ColoRectal Audit (DCRA), between January 2015 and December 2017. Primary outcome was circumferential resection margin (CRM) involvement. Secondary outcomes included operative details and short-term (RESULTS: There were 3,777 patients included for analysis (TaTME, n = 416, lapTME, n = 3361). Transanal TME was performed in 38 hospitals and lapTME in 90 hospitals. Before matching, the patient category within the TaTME group was technically more challenging in terms of tumor height and preoperative threatened margins. After 1: 1 matching, 396 patients were included in each group, with comparable baseline characteristics. Circumferential resection margin involvement was 4.3% after TaTME and 4.0% after lapTME (p = 1.000). Conversion rate was significantly lower in TaTME (1.5% vs 8.6%, p <0.001). Anastomotic leak rate was not significantly different (16.5% vs 12.2%, p = 0.116). Other postoperative outcomes were also comparable between the groups. Significant independent risk factors for CRM involvement in TaTME were preoperative threatened margin on MRI (odds ratio [OR] 5.48, 95% CI 1.33 to 22.54) and conversion (OR 30.12, 95% CI 3.70 to 245.20).CONCLUSIONS: This first nationwide study shows early experience with adoption of TaTME in the Netherlands. Considering that current data represent initial TaTME experience, acceptable short-term outcomes were demonstrated when compared with the well-established lapTME. (C) 2019 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.
AB - BACKGROUND: Transanal total mesorectal excision (TaTME) is a relatively new and demanding technique for rectal cancer treatment. Results from national datasets are absent and comparative data with laparoscopic TME (lapTME) are scarce. Therefore, this study aimed to evaluate the initial TaTME experience in the Netherlands, by comparing outcomes with conventional lapTME.STUDY DESIGN: Patients with rectal cancer who underwent curative TaTME or lapTME were selected from the nationwide and mandatory Dutch ColoRectal Audit (DCRA), between January 2015 and December 2017. Primary outcome was circumferential resection margin (CRM) involvement. Secondary outcomes included operative details and short-term (RESULTS: There were 3,777 patients included for analysis (TaTME, n = 416, lapTME, n = 3361). Transanal TME was performed in 38 hospitals and lapTME in 90 hospitals. Before matching, the patient category within the TaTME group was technically more challenging in terms of tumor height and preoperative threatened margins. After 1: 1 matching, 396 patients were included in each group, with comparable baseline characteristics. Circumferential resection margin involvement was 4.3% after TaTME and 4.0% after lapTME (p = 1.000). Conversion rate was significantly lower in TaTME (1.5% vs 8.6%, p <0.001). Anastomotic leak rate was not significantly different (16.5% vs 12.2%, p = 0.116). Other postoperative outcomes were also comparable between the groups. Significant independent risk factors for CRM involvement in TaTME were preoperative threatened margin on MRI (odds ratio [OR] 5.48, 95% CI 1.33 to 22.54) and conversion (OR 30.12, 95% CI 3.70 to 245.20).CONCLUSIONS: This first nationwide study shows early experience with adoption of TaTME in the Netherlands. Considering that current data represent initial TaTME experience, acceptable short-term outcomes were demonstrated when compared with the well-established lapTME. (C) 2019 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.
KW - ANASTOMOTIC LEAKAGE
KW - PATHOLOGICAL OUTCOMES
KW - ASSISTED RESECTION
KW - CLINICAL-OUTCOMES
KW - SURGERY
KW - RECURRENCE
KW - CONVERSION
KW - TATME
KW - TME
U2 - 10.1016/j.jamcollsurg.2018.12.016
DO - 10.1016/j.jamcollsurg.2018.12.016
M3 - Article
C2 - 30639298
SN - 1072-7515
VL - 228
SP - 235-244.e1
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
IS - 3
ER -