TY - JOUR
T1 - The Montreux definition of neonatal ARDS
T2 - biological and clinical background behind the description of a new entity
AU - De Luca, Daniele
AU - van Kaam, Anton H.
AU - Tingay, David G.
AU - Courtney, Sherry E.
AU - Danhaive, Olivier
AU - Carnielli, Virgilio P.
AU - Zimmermann, Luc J.
AU - Kneyber, Martin C. J.
AU - Tissieres, Pierre
AU - Brierley, Joe
AU - Conti, Giorgio
AU - Pillow, Jane J.
AU - Rimensberger, Peter C.
PY - 2017/8
Y1 - 2017/8
N2 - Acute respiratory distress syndrome (ARDS) is undefined in neonates, despite the long-standing existing formal recognition of ARDS syndrome in later life. We describe the Neonatal ARDS Project: an international, collaborative, multicentre, and multidisciplinary project which aimed to produce an ARDS consensus definition for neonates that is applicable from the perinatal period. The definition was created through discussions between five expert members of the European Society for Paediatric and Neonatal Intensive Care; four experts of the European Society for Paediatric Research; two independent experts from the USA and two from Australia. This Position Paper provides the first consensus definition for neonatal ARDS (called the Montreux definition). We also provide expert consensus that mechanisms causing ARDS in adults and older children-namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volume, increased shunt, and diffuse alveolar damage-are also present in several critical neonatal respiratory disorders.
AB - Acute respiratory distress syndrome (ARDS) is undefined in neonates, despite the long-standing existing formal recognition of ARDS syndrome in later life. We describe the Neonatal ARDS Project: an international, collaborative, multicentre, and multidisciplinary project which aimed to produce an ARDS consensus definition for neonates that is applicable from the perinatal period. The definition was created through discussions between five expert members of the European Society for Paediatric and Neonatal Intensive Care; four experts of the European Society for Paediatric Research; two independent experts from the USA and two from Australia. This Position Paper provides the first consensus definition for neonatal ARDS (called the Montreux definition). We also provide expert consensus that mechanisms causing ARDS in adults and older children-namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volume, increased shunt, and diffuse alveolar damage-are also present in several critical neonatal respiratory disorders.
KW - RESPIRATORY-DISTRESS-SYNDROME
KW - ACUTE LUNG INJURY
KW - BRONCHOALVEOLAR LAVAGE FLUID
KW - HYALINE-MEMBRANE DISEASE
KW - CUTANEOUS CARBON-DIOXIDE
KW - ARTERIAL OXYGEN-TENSION
KW - CONSENSUS CONFERENCE
KW - BERLIN DEFINITION
KW - NEWBORN-INFANTS
KW - INTENSIVE-CARE
U2 - 10.1016/S2213-2600(17)30214-X
DO - 10.1016/S2213-2600(17)30214-X
M3 - Article
SN - 2213-2600
VL - 5
SP - 657
EP - 666
JO - The Lancet Respiratory medicine
JF - The Lancet Respiratory medicine
IS - 8
ER -