The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension

Monica T. J. Schutten, Alfons J. H. M. Houben, Peter W. de Leeuw, Coen D. A. Stehouwer*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

Original languageEnglish
Pages (from-to)197-209
Number of pages13
JournalPhysiology
Volume32
Issue number3
DOIs
Publication statusPublished - May 2017

Keywords

  • ROSTRAL VENTROLATERAL MEDULLA
  • DIET-INDUCED OBESITY
  • SMOOTH-MUSCLE-CELLS
  • CONVERTING ENZYME 2
  • TUBULE NA+-ATPASE
  • MINERALOCORTICOID RECEPTOR ANTAGONISM
  • IMPROVES ENDOTHELIAL FUNCTION
  • INDUCED CAPILLARY RECRUITMENT
  • SYMPATHETIC AFFERENT REFLEX
  • INSULINS METABOLIC ACTION

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