The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts.

D. Lizarraga Lopez; C. Lorenzo; J.J. Briedé; J.H. van Delft; S. Touriño; J.J. Centelles; J.L. Torres; M. Cascante

doi:10.1111/j.1742-4658.2007.06010.x

The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts.

D. Lizarraga Lopez, C. Lorenzo, J.J. Briedé, J.H. van Delft, S. Touriño, J.J. Centelles, J.L. Torres, M. Cascante^*

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation.

Original language	English
Pages (from-to)	4802-4811
Journal	FEBS Journal
Volume	274
Issue number	18
DOIs	https://doi.org/10.1111/j.1742-4658.2007.06010.x
Publication status	Published - 1 Jan 2007

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10.1111/j.1742-4658.2007.06010.x

Cite this

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title = "The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts.",

abstract = "Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation.",

author = "{Lizarraga Lopez}, D. and C. Lorenzo and J.J. Bried{\'e} and {van Delft}, J.H. and S. Touri{\~n}o and J.J. Centelles and J.L. Torres and M. Cascante",

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doi = "10.1111/j.1742-4658.2007.06010.x",

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T1 - The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts.

AU - Lizarraga Lopez, D.

AU - Lorenzo, C.

AU - Briedé, J.J.

AU - van Delft, J.H.

AU - Touriño, S.

AU - Centelles, J.J.

AU - Torres, J.L.

AU - Cascante, M.

PY - 2007/1/1

Y1 - 2007/1/1

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AB - Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation.

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DO - 10.1111/j.1742-4658.2007.06010.x

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