Abstract
This randomized, double-blind, parallel-group, multicenter study compared the efficacy of amlodipine and losartan in an older hypertensive population, focusing on therapeutic coverage in the case of missed doses. Following a 4-week, single-blind, placebo washout period, 211 patients were randomly assigned to receive either 5 mg of amlodipine once daily or 50 mg of losartan once daily. Doses were doubled after 6 weeks of treatment if the diastolic blood pressure exceeded 90 mm Hg. After the 12-week treatment period, patients received the placebo for 2 days (drug holiday) to simulate two missed doses of antihypertensive medication. Twenty-four-hour ambulatory blood pressure monitoring was conducted at the end of the placebo washout period (baseline), upon completion of the 12-week treatment period (steady state), and after the 2-day drug holiday. Amlodipine was more effective than losartan in reducing patients' 24-h ambulatory blood pressure at the steady-state sampling time. The increases in 24-h blood pressure during the drug holiday averaged 6 +/- 2/2 +/- 1 mm Hg (P
Original language | English |
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Pages (from-to) | 568-572 |
Number of pages | 5 |
Journal | Hypertension Research |
Volume | 40 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2017 |
Keywords
- amlodipine
- drug holiday
- losartan
- therapeutic coverage
- PHARMACOKINETICS
- ANTAGONIST