The effects of metformin on metabolism and cardiovascular disease in type 2 diabetes

J. de Jager

doi:10.26481/dis.20100527jj

The effects of metformin on metabolism and cardiovascular disease in type 2 diabetes

J. de Jager

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Abstract

Patients with diabetes type 2 benefit from continuing the metformin treatment when the moment has come that insulin administering becomes necessary. This is shown by this research that studied the long-term (4.3 years) effects of metformin on among others cardiovascular diseases. The metformin induced improvement in cardiovascular diseases was partly explained by weight loss and improvement in endothelial function in the metformin group, but not by lower insulin levels. Finally, long-term metformin treatment turned out to considerably decrease the risk of developing a vitamin B12 deficiency. The present guidelines, however, don’t make recommendations for the prevention and detection of vitamin B12 deficiencies during the metformin treatment. This research presents strong arguments for the routine determination of vitamin B12 during the metformin treatment.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Stehouwer, Coen, Supervisor Kooy, A., Co-Supervisor, External person
Award date	27 May 2010
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789490371197
DOIs	https://doi.org/10.26481/dis.20100527jj
Publication status	Published - 1 Jan 2010

Keywords

metformin
vitamin B12
inflammation
endothelial dysfunction
cardiovascular diseases

Access to Document

10.26481/dis.20100527jj

Full TextFinal published version, 1.46 MB
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AbstractFinal published version, 222 KB
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Cite this

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title = "The effects of metformin on metabolism and cardiovascular disease in type 2 diabetes",

abstract = "Patients with diabetes type 2 benefit from continuing the metformin treatment when the moment has come that insulin administering becomes necessary. This is shown by this research that studied the long-term (4.3 years) effects of metformin on among others cardiovascular diseases. The metformin induced improvement in cardiovascular diseases was partly explained by weight loss and improvement in endothelial function in the metformin group, but not by lower insulin levels. Finally, long-term metformin treatment turned out to considerably decrease the risk of developing a vitamin B12 deficiency. The present guidelines, however, don{\textquoteright}t make recommendations for the prevention and detection of vitamin B12 deficiencies during the metformin treatment. This research presents strong arguments for the routine determination of vitamin B12 during the metformin treatment. ",

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