The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis

Claudia Vingerhoets; Geor Bakker; Jelske van Dijik; Oswald J. N. Bloemen; Ya Wang; Raymond C. K. Chan; Jan Booij; Therese A. M. J. van Amelsvoort

doi:10.1016/j.euroneuro.2017.06.014

The effect of the muscarinic M₁ receptor antagonist biperiden on cognition in medication free subjects with psychosis

Claudia Vingerhoets^*, Geor Bakker, Jelske van Dijik, Oswald J. N. Bloemen, Ya Wang, Raymond C. K. Chan, Jan Booij, Therese A. M. J. van Amelsvoort

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p

Original language	English
Pages (from-to)	854-864
Number of pages	11
Journal	European Neuropsychopharmacology
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.euroneuro.2017.06.014
Publication status	Published - Sept 2017

Keywords

Psychosis
Muscarinic M-1 receptor
Acetylcholine
Cognition
Biperiden
HEALTHY-VOLUNTEERS
PREFRONTAL CORTEX
SCHIZOPHRENIA
BINDING
MEMORY
PSYCHOPATHOLOGY
RELIABILITY
SENSITIVITY
SCOPOLAMINE
IMPAIRMENT

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10.1016/j.euroneuro.2017.06.014

Cite this

@article{179ec9c716df442bb5eda5249ca41a4d,

title = "The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis",

abstract = "The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p",

keywords = "Psychosis, Muscarinic M-1 receptor, Acetylcholine, Cognition, Biperiden, HEALTHY-VOLUNTEERS, PREFRONTAL CORTEX, SCHIZOPHRENIA, BINDING, MEMORY, PSYCHOPATHOLOGY, RELIABILITY, SENSITIVITY, SCOPOLAMINE, IMPAIRMENT",

author = "Claudia Vingerhoets and Geor Bakker and {van Dijik}, Jelske and Bloemen, {Oswald J. N.} and Ya Wang and Chan, {Raymond C. K.} and Jan Booij and {van Amelsvoort}, {Therese A. M. J.}",

year = "2017",

month = sep,

doi = "10.1016/j.euroneuro.2017.06.014",

language = "English",

volume = "27",

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journal = "European Neuropsychopharmacology",

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AU - Vingerhoets, Claudia

AU - Bakker, Geor

AU - van Dijik, Jelske

AU - Bloemen, Oswald J. N.

AU - Wang, Ya

AU - Chan, Raymond C. K.

AU - Booij, Jan

AU - van Amelsvoort, Therese A. M. J.

PY - 2017/9

Y1 - 2017/9

N2 - The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p

AB - The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p

KW - Psychosis

KW - Muscarinic M-1 receptor

KW - Acetylcholine

KW - Cognition

KW - Biperiden

KW - HEALTHY-VOLUNTEERS

KW - PREFRONTAL CORTEX

KW - SCHIZOPHRENIA

KW - BINDING

KW - MEMORY

KW - PSYCHOPATHOLOGY

KW - RELIABILITY

KW - SENSITIVITY

KW - SCOPOLAMINE

KW - IMPAIRMENT

U2 - 10.1016/j.euroneuro.2017.06.014

DO - 10.1016/j.euroneuro.2017.06.014

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JO - European Neuropsychopharmacology

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