TY - JOUR
T1 - The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes The CODAM study
AU - Hertle, Elisabeth
AU - Arts, Ilja C. W.
AU - van der Kallen, Carla J. H.
AU - Feskens, Edith J. M.
AU - Schalkwijk, Casper G.
AU - Stehouwer, Coen D. A.
AU - van Greevenbroek, Marleen M. J.
PY - 2016/2
Y1 - 2016/2
N2 - The alternative pathway of complement activation is highly reactive and can be activated spontaneously in the vasculature. Activation may contribute to vascular damage and development of cardiovascular disease (CVD). We aimed to investigate functional components of the alternative pathway in cardiovascular risk. We studied 573 individuals who were followed-up for seven years. At baseline, we measured the enhancer properdin; the rate-limiting protease factor D (FD); and a marker of systemic activation, Bb. Using generalised estimating equations, we investigated their longitudinal associations with cardiovascular events (CVE, N=89), CVD (N=159), low-grade inflammation (LGI), endothelial dysfunction (ED) and carotid intima-media thickness (cIMT). Furthermore, we investigated associations with incident CVE (N=39) and CVD (N=73) in 342 participants free of CVD at baseline. CVE included myocardial infarction, stroke, cardiac angioplasty and/or cardiac bypass. CVD additionally included ischaemia on an electrocardiogram and/or ankle-brachial index
AB - The alternative pathway of complement activation is highly reactive and can be activated spontaneously in the vasculature. Activation may contribute to vascular damage and development of cardiovascular disease (CVD). We aimed to investigate functional components of the alternative pathway in cardiovascular risk. We studied 573 individuals who were followed-up for seven years. At baseline, we measured the enhancer properdin; the rate-limiting protease factor D (FD); and a marker of systemic activation, Bb. Using generalised estimating equations, we investigated their longitudinal associations with cardiovascular events (CVE, N=89), CVD (N=159), low-grade inflammation (LGI), endothelial dysfunction (ED) and carotid intima-media thickness (cIMT). Furthermore, we investigated associations with incident CVE (N=39) and CVD (N=73) in 342 participants free of CVD at baseline. CVE included myocardial infarction, stroke, cardiac angioplasty and/or cardiac bypass. CVD additionally included ischaemia on an electrocardiogram and/or ankle-brachial index
KW - Alternative complement pathway
KW - properdin
KW - cardiovascular events
KW - endothelial dysfunction
U2 - 10.1160/TH15-05-0439
DO - 10.1160/TH15-05-0439
M3 - Article
C2 - 26446431
SN - 0340-6245
VL - 115
SP - 446
EP - 457
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 2
ER -