TY - JOUR
T1 - Temporary antiretroviral treatment during primary HIV-1 infection has a positive impact on health-related quality of life: data from the Primo-SHM cohort study.
AU - Grijsen, M
AU - Koster, G.
AU - van Vonderen, M.G.A.
AU - van Kasteren, M. E.
AU - Kootstra, G.
AU - Steingrover, R
AU - de Wolf, F.
AU - Prins, J.
AU - Nieuwkerk, P.T.
AU - PRIMO-SHM Studygroup (incl. Lowe), S.H.
AU - PRIMO-SHM Studygroup (incl. Oude Lashof), A.M.
PY - 2012/11
Y1 - 2012/11
N2 - Objectives The aim of the study was to compare health-related quality of life (HRQL) over 96 weeks in patients receiving no treatment or 24 or 60 weeks of combination antiretroviral therapy (cART) during primary HIV-1 infection (PHI). Methods A multicentre prospective cohort study of PHI patients, with an embedded randomized trial, was carried out. HRQL was assessed with the Medical Outcomes Study Health Survey for HIV (MOS-HIV) and a symptom checklist administered at weeks 0, 8, 24, 36, 48, 60, 72, 84 and 96. Mixed linear models were used for the analysis of differences in HRQL among the three groups. Results A total of 112 patients were included in the study: 28 received no treatment, 45 received 24 weeks of cART and 39 received 60 weeks of cART. Over 96 weeks of follow-up, the groups receiving 24 and 60 weeks of cART had better cognitive functioning than the no-treatment group (P?=?0.005). Patients receiving 60 weeks of cART had less pain (P?=?0.004), better role functioning (P?=?0.001), better physical functioning (P?=?0.02) and a better physical health summary score (P?=?0.006) than the groups receiving no treatment or 24 weeks of cART. Mental health was better in patients receiving 24 weeks of cART than in patients in the no-treatment group or the group receiving 60 weeks of cART (P?=?0.02). At week 8, patients in the groups receiving 24 and 60 weeks of cART reported more nausea (P?=?0.002), diarrhoea (P?
AB - Objectives The aim of the study was to compare health-related quality of life (HRQL) over 96 weeks in patients receiving no treatment or 24 or 60 weeks of combination antiretroviral therapy (cART) during primary HIV-1 infection (PHI). Methods A multicentre prospective cohort study of PHI patients, with an embedded randomized trial, was carried out. HRQL was assessed with the Medical Outcomes Study Health Survey for HIV (MOS-HIV) and a symptom checklist administered at weeks 0, 8, 24, 36, 48, 60, 72, 84 and 96. Mixed linear models were used for the analysis of differences in HRQL among the three groups. Results A total of 112 patients were included in the study: 28 received no treatment, 45 received 24 weeks of cART and 39 received 60 weeks of cART. Over 96 weeks of follow-up, the groups receiving 24 and 60 weeks of cART had better cognitive functioning than the no-treatment group (P?=?0.005). Patients receiving 60 weeks of cART had less pain (P?=?0.004), better role functioning (P?=?0.001), better physical functioning (P?=?0.02) and a better physical health summary score (P?=?0.006) than the groups receiving no treatment or 24 weeks of cART. Mental health was better in patients receiving 24 weeks of cART than in patients in the no-treatment group or the group receiving 60 weeks of cART (P?=?0.02). At week 8, patients in the groups receiving 24 and 60 weeks of cART reported more nausea (P?=?0.002), diarrhoea (P?
KW - acute HIV infection
KW - combination antiretroviral therapy
KW - health-related quality of life
KW - primary HIV infection
KW - MEDICAL OUTCOMES
KW - THERAPY
KW - TRIAL
U2 - 10.1111/j.1468-1293.2012.01020.x
DO - 10.1111/j.1468-1293.2012.01020.x
M3 - Article
C2 - 22533544
SN - 1464-2662
VL - 13
SP - 630
EP - 635
JO - HIV Medicine
JF - HIV Medicine
IS - 10
ER -