TY - JOUR
T1 - Targeting the Wnt/frizzled signaling pathway after myocardial infarction: A new tool in the therapeutic toolbox?
AU - Daskalopoulos, Evangelos P.
AU - Hermans, Kevin C. M.
AU - Janssen, Ben J. A.
AU - Blankesteijn, W. Matthijs
PY - 2013/5
Y1 - 2013/5
N2 - Wnt/frizzled signaling in the adult heart is quiescent under normal conditions; however it is reactivated after myocardial infarction (MI). Any intervention at the various levels of this pathway can modulate its signaling. Several studies have targeted Wnt/frizzled signaling after MI with the majority of them indicating that the inhibition of the pathway is beneficial since it improves infarct healing and prevents heart failure. This suggests that blocking the Wnt/frizzled signaling pathway could be a potential novel therapeutic target to prevent the adverse cardiac remodeling after MI.
AB - Wnt/frizzled signaling in the adult heart is quiescent under normal conditions; however it is reactivated after myocardial infarction (MI). Any intervention at the various levels of this pathway can modulate its signaling. Several studies have targeted Wnt/frizzled signaling after MI with the majority of them indicating that the inhibition of the pathway is beneficial since it improves infarct healing and prevents heart failure. This suggests that blocking the Wnt/frizzled signaling pathway could be a potential novel therapeutic target to prevent the adverse cardiac remodeling after MI.
U2 - 10.1016/j.tcm.2012.09.010
DO - 10.1016/j.tcm.2012.09.010
M3 - Article
C2 - 23266229
SN - 1050-1738
VL - 23
SP - 121
EP - 127
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 4
ER -