T2 weighted signal intensity evolution may predict pathological complete response after treatment for rectal cancer.

E. Kluza; E. D. Rozeboom; M. Maas; M. Martens; D.M. Lambregts; J. Slenter; G.L. Beets; R.G.H. Beets-Tan

doi:10.1007/s00330-012-2578-z

T2 weighted signal intensity evolution may predict pathological complete response after treatment for rectal cancer.

E. Kluza^*, E. D. Rozeboom, M. Maas, M. Martens, D.M. Lambregts, J. Slenter, G.L. Beets, R.G.H. Beets-Tan

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: To determine the diagnostic value of T2-weighted signal intensity evolution in the tumour for detection of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancer. METHODS: Thirty-nine patients diagnosed with locally advanced adenocarcinoma and treated with chemoradiotherapy (CRT), followed by surgery, underwent magnetic resonance imaging (MRI) before and after CRT on 1.5-T MRI using T2-weighted fast spin-echo (FSE) imaging. The relative T2-weighted signal intensity (rT2wSI) distribution in the tumour and post-CRT residual tissue was characterised by means of the descriptive statistical parameters, such as the mean, 95th percentile and standard deviation (SD). Receiver operating characteristic curves were used to determine the diagnostic potential of the CRT-induced alterations (Delta) in rT2wSI descriptives. The tumour regression grade (TRG) served as a histopathological reference standard. RESULTS: CRT induced a significant decrease of approximately 50% in all rT2wSI descriptives in complete responders (TRG1). This drop was significantly larger than for incomplete response groups (TRG2-TRG4). The DeltarT2wSI descriptives produced a high diagnostic performance for identification of complete responders, e.g. Delta95th percentile, DeltaSD and Deltamean resulted in accuracy of 92%, 90% and 82%, respectively. CONCLUSIONS: Quantitative assessment of the CRT-induced changes in the tumour T2-weighted signal intensity provides high diagnostic performance for selection of complete responders. KEY POINTS : * T2 weighted MRI helps predict response after chemoradiotherapy for rectal cancer. * Residual tumour and chemoradiotherapy-induced fibrosis have different T2 relaxation properties. * T2-weighted signal intensity evolution is a promising non-invasive marker of therapeutic response. * A pathologically complete response is associated with the largest signal intensity drop.

Original language	English
Pages (from-to)	253-261
Journal	European Radiology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s00330-012-2578-z
Publication status	Published - 1 Jan 2013

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@article{eee2dcc00bf14f5495cf1febe53a6f97,

title = "T2 weighted signal intensity evolution may predict pathological complete response after treatment for rectal cancer.",

abstract = "OBJECTIVES: To determine the diagnostic value of T2-weighted signal intensity evolution in the tumour for detection of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancer. METHODS: Thirty-nine patients diagnosed with locally advanced adenocarcinoma and treated with chemoradiotherapy (CRT), followed by surgery, underwent magnetic resonance imaging (MRI) before and after CRT on 1.5-T MRI using T2-weighted fast spin-echo (FSE) imaging. The relative T2-weighted signal intensity (rT2wSI) distribution in the tumour and post-CRT residual tissue was characterised by means of the descriptive statistical parameters, such as the mean, 95th percentile and standard deviation (SD). Receiver operating characteristic curves were used to determine the diagnostic potential of the CRT-induced alterations (Delta) in rT2wSI descriptives. The tumour regression grade (TRG) served as a histopathological reference standard. RESULTS: CRT induced a significant decrease of approximately 50% in all rT2wSI descriptives in complete responders (TRG1). This drop was significantly larger than for incomplete response groups (TRG2-TRG4). The DeltarT2wSI descriptives produced a high diagnostic performance for identification of complete responders, e.g. Delta95th percentile, DeltaSD and Deltamean resulted in accuracy of 92%, 90% and 82%, respectively. CONCLUSIONS: Quantitative assessment of the CRT-induced changes in the tumour T2-weighted signal intensity provides high diagnostic performance for selection of complete responders. KEY POINTS : * T2 weighted MRI helps predict response after chemoradiotherapy for rectal cancer. * Residual tumour and chemoradiotherapy-induced fibrosis have different T2 relaxation properties. * T2-weighted signal intensity evolution is a promising non-invasive marker of therapeutic response. * A pathologically complete response is associated with the largest signal intensity drop.",

author = "E. Kluza and Rozeboom, {E. D.} and M. Maas and M. Martens and D.M. Lambregts and J. Slenter and G.L. Beets and R.G.H. Beets-Tan",

year = "2013",

month = jan,

day = "1",

doi = "10.1007/s00330-012-2578-z",

language = "English",

volume = "23",

pages = "253--261",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer, Cham",

number = "1",

}

TY - JOUR

T1 - T2 weighted signal intensity evolution may predict pathological complete response after treatment for rectal cancer.

AU - Kluza, E.

AU - Rozeboom, E. D.

AU - Maas, M.

AU - Martens, M.

AU - Lambregts, D.M.

AU - Slenter, J.

AU - Beets, G.L.

AU - Beets-Tan, R.G.H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - OBJECTIVES: To determine the diagnostic value of T2-weighted signal intensity evolution in the tumour for detection of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancer. METHODS: Thirty-nine patients diagnosed with locally advanced adenocarcinoma and treated with chemoradiotherapy (CRT), followed by surgery, underwent magnetic resonance imaging (MRI) before and after CRT on 1.5-T MRI using T2-weighted fast spin-echo (FSE) imaging. The relative T2-weighted signal intensity (rT2wSI) distribution in the tumour and post-CRT residual tissue was characterised by means of the descriptive statistical parameters, such as the mean, 95th percentile and standard deviation (SD). Receiver operating characteristic curves were used to determine the diagnostic potential of the CRT-induced alterations (Delta) in rT2wSI descriptives. The tumour regression grade (TRG) served as a histopathological reference standard. RESULTS: CRT induced a significant decrease of approximately 50% in all rT2wSI descriptives in complete responders (TRG1). This drop was significantly larger than for incomplete response groups (TRG2-TRG4). The DeltarT2wSI descriptives produced a high diagnostic performance for identification of complete responders, e.g. Delta95th percentile, DeltaSD and Deltamean resulted in accuracy of 92%, 90% and 82%, respectively. CONCLUSIONS: Quantitative assessment of the CRT-induced changes in the tumour T2-weighted signal intensity provides high diagnostic performance for selection of complete responders. KEY POINTS : * T2 weighted MRI helps predict response after chemoradiotherapy for rectal cancer. * Residual tumour and chemoradiotherapy-induced fibrosis have different T2 relaxation properties. * T2-weighted signal intensity evolution is a promising non-invasive marker of therapeutic response. * A pathologically complete response is associated with the largest signal intensity drop.

AB - OBJECTIVES: To determine the diagnostic value of T2-weighted signal intensity evolution in the tumour for detection of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancer. METHODS: Thirty-nine patients diagnosed with locally advanced adenocarcinoma and treated with chemoradiotherapy (CRT), followed by surgery, underwent magnetic resonance imaging (MRI) before and after CRT on 1.5-T MRI using T2-weighted fast spin-echo (FSE) imaging. The relative T2-weighted signal intensity (rT2wSI) distribution in the tumour and post-CRT residual tissue was characterised by means of the descriptive statistical parameters, such as the mean, 95th percentile and standard deviation (SD). Receiver operating characteristic curves were used to determine the diagnostic potential of the CRT-induced alterations (Delta) in rT2wSI descriptives. The tumour regression grade (TRG) served as a histopathological reference standard. RESULTS: CRT induced a significant decrease of approximately 50% in all rT2wSI descriptives in complete responders (TRG1). This drop was significantly larger than for incomplete response groups (TRG2-TRG4). The DeltarT2wSI descriptives produced a high diagnostic performance for identification of complete responders, e.g. Delta95th percentile, DeltaSD and Deltamean resulted in accuracy of 92%, 90% and 82%, respectively. CONCLUSIONS: Quantitative assessment of the CRT-induced changes in the tumour T2-weighted signal intensity provides high diagnostic performance for selection of complete responders. KEY POINTS : * T2 weighted MRI helps predict response after chemoradiotherapy for rectal cancer. * Residual tumour and chemoradiotherapy-induced fibrosis have different T2 relaxation properties. * T2-weighted signal intensity evolution is a promising non-invasive marker of therapeutic response. * A pathologically complete response is associated with the largest signal intensity drop.

U2 - 10.1007/s00330-012-2578-z

DO - 10.1007/s00330-012-2578-z

M3 - Article

SN - 0938-7994

VL - 23

SP - 253

EP - 261

JO - European Radiology

JF - European Radiology

IS - 1

ER -