TY - JOUR
T1 - Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations
AU - Wouters, E.F.
AU - Groenewegen, K.H.
AU - Dentener, M.A.
AU - Vernooy, J.H.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal studies. Most of the systemic manifestations are likely the result of inflammatory processes. Serum biomarkers, such as various cytokines, adipokines, C-reactive protein, and coagulation factors, are elevated during exacerbations. Our understanding of the systemic manifestations can be greatly enhanced if we integrate what is known about the basic science of systemic mediators with the translational science of their role in COPD exacerbations. Many overlapping connections and promising avenues of future research come to light with such a viewpoint.
AB - The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal studies. Most of the systemic manifestations are likely the result of inflammatory processes. Serum biomarkers, such as various cytokines, adipokines, C-reactive protein, and coagulation factors, are elevated during exacerbations. Our understanding of the systemic manifestations can be greatly enhanced if we integrate what is known about the basic science of systemic mediators with the translational science of their role in COPD exacerbations. Many overlapping connections and promising avenues of future research come to light with such a viewpoint.
U2 - 10.1513/pats.200706-071TH
DO - 10.1513/pats.200706-071TH
M3 - Article
SN - 1546-3222
VL - 4
SP - 626
EP - 634
JO - Proceedings of the American Thoracic Society : an official publication of the American Thoracic Society
JF - Proceedings of the American Thoracic Society : an official publication of the American Thoracic Society
IS - 8
ER -