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Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

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Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy. / Wigman, J.T.W.; van Os, J.; Abidi, L.; Huibers, M.J.H.; Roelofs, J.; Arntz, A.; Kelleher, I.; Peeters, F.P.M.L.

In: Psychological Medicine, Vol. 44, No. 2, 01.01.2014, p. 325-336.

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Wigman, J.T.W. ; van Os, J. ; Abidi, L. ; Huibers, M.J.H. ; Roelofs, J. ; Arntz, A. ; Kelleher, I. ; Peeters, F.P.M.L. / Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy. In: Psychological Medicine. 2014 ; Vol. 44, No. 2. pp. 325-336.

Bibtex

@article{626e56c7ac2341b09f59c4a6f38830db,
title = "Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy",
abstract = "BACKGROUND: Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy. METHOD: In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point. RESULTS: Subclinical psychotic experiences predicted more depression over time (beta = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037). CONCLUSIONS: In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.",
author = "J.T.W. Wigman and {van Os}, J. and L. Abidi and M.J.H. Huibers and J. Roelofs and A. Arntz and I. Kelleher and F.P.M.L. Peeters",
year = "2014",
month = "1",
day = "1",
doi = "10.1017/S0033291713000871",
language = "English",
volume = "44",
pages = "325--336",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

AU - Wigman, J.T.W.

AU - van Os, J.

AU - Abidi, L.

AU - Huibers, M.J.H.

AU - Roelofs, J.

AU - Arntz, A.

AU - Kelleher, I.

AU - Peeters, F.P.M.L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy. METHOD: In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point. RESULTS: Subclinical psychotic experiences predicted more depression over time (beta = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037). CONCLUSIONS: In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.

AB - BACKGROUND: Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy. METHOD: In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point. RESULTS: Subclinical psychotic experiences predicted more depression over time (beta = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037). CONCLUSIONS: In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.

U2 - 10.1017/S0033291713000871

DO - 10.1017/S0033291713000871

M3 - Article

VL - 44

SP - 325

EP - 336

JO - Psychological Medicine

T2 - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 2

ER -