Smoking as a risk factor for developing Multiple Sclerosis: A meta-analysis of observational studies

I. Backhaus; A. Mannocci; Paul Lemmens; G. La Torre

doi:10.7417/CT.2016.1932

Smoking as a risk factor for developing Multiple Sclerosis: A meta-analysis of observational studies

I. Backhaus, A. Mannocci, Paul Lemmens, G. La Torre

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of this study was to improve and update the pool of available studies included in the previous meta-analyses, and to provide further evidence about smoking as a risk factor for MS.PubMed and Scopus searches were undertaken to identify studies investigating the association between cigarette smoking and MS. Odds ratio (OR), relative risk (RR) together with 95% confidence intervals (CIs) were calculated for case-control and cohort studies and prevalence rate for cross sectional.33 studies were suitable for the meta-analysis. The summary OR for case control studies (ever versus never) was 1.40 (95% CI, 1.29 to 1.52) and 1.42 (1.26-1.60) for current vs. no-smokers.Smoking is associated with MS risk. Research using animal models can help to fully understand the mechanisms behind the association.

Original language	English
Pages (from-to)	82-92
Journal	Clinica Terapeutica
Volume	167
Issue number	3
DOIs	https://doi.org/10.7417/CT.2016.1932
Publication status	Published - 2016

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10.7417/CT.2016.1932

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title = "Smoking as a risk factor for developing Multiple Sclerosis: A meta-analysis of observational studies",

abstract = "The aim of this study was to improve and update the pool of available studies included in the previous meta-analyses, and to provide further evidence about smoking as a risk factor for MS.PubMed and Scopus searches were undertaken to identify studies investigating the association between cigarette smoking and MS. Odds ratio (OR), relative risk (RR) together with 95% confidence intervals (CIs) were calculated for case-control and cohort studies and prevalence rate for cross sectional.33 studies were suitable for the meta-analysis. The summary OR for case control studies (ever versus never) was 1.40 (95% CI, 1.29 to 1.52) and 1.42 (1.26-1.60) for current vs. no-smokers.Smoking is associated with MS risk. Research using animal models can help to fully understand the mechanisms behind the association.",

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AU - La Torre, G.

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AB - The aim of this study was to improve and update the pool of available studies included in the previous meta-analyses, and to provide further evidence about smoking as a risk factor for MS.PubMed and Scopus searches were undertaken to identify studies investigating the association between cigarette smoking and MS. Odds ratio (OR), relative risk (RR) together with 95% confidence intervals (CIs) were calculated for case-control and cohort studies and prevalence rate for cross sectional.33 studies were suitable for the meta-analysis. The summary OR for case control studies (ever versus never) was 1.40 (95% CI, 1.29 to 1.52) and 1.42 (1.26-1.60) for current vs. no-smokers.Smoking is associated with MS risk. Research using animal models can help to fully understand the mechanisms behind the association.

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