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Sleep EEG characteristics associated with sleep onset misperception

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Sleep EEG characteristics associated with sleep onset misperception. / Hermans, Lieke W A; Leufkens, Tim R; van Gilst, Merel M; Weysen, Tim; Ross, Marco; Anderer, Peter; Overeem, Sebastiaan; Vermeeren, Annemiek.

In: Sleep Medicine, Vol. 57, 05.2019, p. 70-79.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Hermans, LWA, Leufkens, TR, van Gilst, MM, Weysen, T, Ross, M, Anderer, P, Overeem, S & Vermeeren, A 2019, 'Sleep EEG characteristics associated with sleep onset misperception', Sleep Medicine, vol. 57, pp. 70-79. https://doi.org/10.1016/j.sleep.2019.01.031

APA

Hermans, L. W. A., Leufkens, T. R., van Gilst, M. M., Weysen, T., Ross, M., Anderer, P., ... Vermeeren, A. (2019). Sleep EEG characteristics associated with sleep onset misperception. Sleep Medicine, 57, 70-79. https://doi.org/10.1016/j.sleep.2019.01.031

Vancouver

Hermans LWA, Leufkens TR, van Gilst MM, Weysen T, Ross M, Anderer P et al. Sleep EEG characteristics associated with sleep onset misperception. Sleep Medicine. 2019 May;57:70-79. https://doi.org/10.1016/j.sleep.2019.01.031

Author

Hermans, Lieke W A ; Leufkens, Tim R ; van Gilst, Merel M ; Weysen, Tim ; Ross, Marco ; Anderer, Peter ; Overeem, Sebastiaan ; Vermeeren, Annemiek. / Sleep EEG characteristics associated with sleep onset misperception. In: Sleep Medicine. 2019 ; Vol. 57. pp. 70-79.

Bibtex

@article{985d7336ab734f11971be99f9f9fed9a,
title = "Sleep EEG characteristics associated with sleep onset misperception",
abstract = "STUDY OBJECTIVE: To study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).METHODS: Data analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.RESULTS: Misperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.CONCLUSIONS: Our findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.",
keywords = "Hyperarousal, INTERMITTENT, Insomnia, PERCEPTION, PERIOD, PRIMARY INSOMNIA, Sleep fragmentation, Sleep onset latency, Sleep state misperception",
author = "Hermans, {Lieke W A} and Leufkens, {Tim R} and {van Gilst}, {Merel M} and Tim Weysen and Marco Ross and Peter Anderer and Sebastiaan Overeem and Annemiek Vermeeren",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = "5",
doi = "10.1016/j.sleep.2019.01.031",
language = "English",
volume = "57",
pages = "70--79",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier Science",

}

RIS

TY - JOUR

T1 - Sleep EEG characteristics associated with sleep onset misperception

AU - Hermans, Lieke W A

AU - Leufkens, Tim R

AU - van Gilst, Merel M

AU - Weysen, Tim

AU - Ross, Marco

AU - Anderer, Peter

AU - Overeem, Sebastiaan

AU - Vermeeren, Annemiek

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - STUDY OBJECTIVE: To study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).METHODS: Data analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.RESULTS: Misperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.CONCLUSIONS: Our findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.

AB - STUDY OBJECTIVE: To study sleep EEG characteristics associated with misperception of Sleep Onset Latency (SOL).METHODS: Data analysis was based on secondary analysis of standard in-lab polysomnographic recordings in 20 elderly people with insomnia and 21 elderly good sleepers. Parameters indicating sleep fragmentation, such as number of awakenings, wake after sleep onset (WASO) and percentage of NREM1 were extracted from the polsysomnogram, as well as spectral power, microarousals and sleep spindle index. The correlation between these parameters during the first sleep cycle and the amount of misperceived sleep was assessed in the insomnia group. Additionally, we made a model of the minimum duration that a sleep fragment at sleep onset should have in order to be perceived as sleep, and we fitted this model to subjective SOLs of both subject groups.RESULTS: Misperception of SOL was associated with increased percentage of NREM1 and more WASO during sleep cycle 1. For insomnia subjects, the best fit of modelled SOL with subjective SOL was found when assuming that sleep fragments shorter than 30 min at sleep onset were perceived as wake. The model indicated that healthy subjects are less sensitive to sleep interruptions and perceive fragments of 10 min or longer as sleep.CONCLUSIONS: Our findings suggest that sleep onset misperception is related to sleep fragmentation at the beginning of the night. Moreover, we show that people with insomnia needed a longer duration of continuous sleep for the perception as such compared to controls. Further expanding the model could provide more detailed information about the underlying mechanisms of sleep misperception.

KW - Hyperarousal

KW - INTERMITTENT

KW - Insomnia

KW - PERCEPTION

KW - PERIOD

KW - PRIMARY INSOMNIA

KW - Sleep fragmentation

KW - Sleep onset latency

KW - Sleep state misperception

U2 - 10.1016/j.sleep.2019.01.031

DO - 10.1016/j.sleep.2019.01.031

M3 - Article

VL - 57

SP - 70

EP - 79

JO - Sleep Medicine

T2 - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

ER -