TY - JOUR
T1 - Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study
AU - van Eupen, Marcelle G. A.
AU - Schram, Miranda T.
AU - van Sloten, Thomas T.
AU - Scheijen, Jean
AU - Sep, Simone J. S.
AU - van der Kallen, Carla J.
AU - Dagnelie, Pieter C.
AU - Koster, Annemarie
AU - Schaper, Nicolaas
AU - Henry, Ronald M. A.
AU - Kroon, Abraham A.
AU - Smit, Andries J.
AU - Stehouwer, Coen D. A.
AU - Schalkwijk, Casper G.
PY - 2016/10
Y1 - 2016/10
N2 - Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (s 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (s 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulse-wave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction
AB - Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (s 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (s 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulse-wave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction
KW - advanced glycation end products
KW - arterial stiffness autofluorescence imaging
KW - blood pressure
KW - pentosidine
U2 - 10.1161/HYPERTENSIONAHA.116.07446
DO - 10.1161/HYPERTENSIONAHA.116.07446
M3 - Article
C2 - 27550921
SN - 0194-911X
VL - 68
SP - 956
EP - 963
JO - Hypertension
JF - Hypertension
IS - 4
ER -